Evidence map›Paper›PMID 41623872›Full record

ArticleFrontiers in cardiovascular medicine2025

A swine model of severe chronic thromboembolic pulmonary hypertension induced by repeated pulmonary artery long suture injection.

Liliana Moreira-Costa, André Leite-Moreira, Rui Adão, David Laville, Marta Tavares-Silva, Isabel Miranda, Rui J Cerqueira, Francisca C Correia, Stéphanie Chanon, Aurélie Vieille-Marchiset and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Large animal models of right heart failure due to pulmonary hypertension: a bridge to translational success.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Liliana Moreira-CostaRISE-Health, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal.
André Leite-MoreiraRISE-Health, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal.
Rui AdãoRISE-Health, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal.
David LavilleLaboratoire CarMeN, UMR INSERM U1060/INRA U1397, University of Lyon, Université Claude Bernard Lyon 1, Pierre-Bénite, France.
Marta Tavares-SilvaRISE-Health, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal.
Isabel MirandaRISE-Health, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal.
Rui J CerqueiraRISE-Health, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal.
Francisca C CorreiaRISE-Health, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal.
Stéphanie ChanonLaboratoire CarMeN, UMR INSERM U1060/INRA U1397, University of Lyon, Université Claude Bernard Lyon 1, Pierre-Bénite, France.
Aurélie Vieille-MarchisetLaboratoire CarMeN, UMR INSERM U1060/INRA U1397, University of Lyon, Université Claude Bernard Lyon 1, Pierre-Bénite, France.
Frédéric PerrosLaboratoire CarMeN, UMR INSERM U1060/INRA U1397, University of Lyon, Université Claude Bernard Lyon 1, Pierre-Bénite, France.
Adelino F Leite-MoreiraRISE-Health, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal.
André P LourençoRISE-Health, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal.
Pedro Mendes-FerreiraRISE-Health, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Large animal models are key to translational research. Current models of chronic thromboembolic pulmonary hypertension (CTEPH) are rather complex, impractical and most fail to achieve a severe PH and right ventricular (RV) dysfunction phenotype. Our aim was to develop a plain large animal model of severe CTEPH with RV dysfunction. Methods: In 3 consecutive weeks, 2-month-old male pigs (∼25 kg) randomly underwent either left and right pulmonary artery (PA) injection of 15-30 15 cm #0 silk sutures (CTEPH, Results: At terminal evaluation, mPAP was consistently higher in CTEPH compared with Sham (51 ± 3 vs. 20 ± 1 mmHg, respectively; Discussion: We developed a new and straightforward swine model of severe CTEPH with RV dysfunction by repeated injection of long sutures into the PA without the need for additional hits which may be valuable for preclinical research.

Indexed as

chronic thromboembolic pulmonary hypertensionpulmonary circulationright ventricleswine modelvascular remodeling

Identifiers

PMID41623872
PMCPMC12856298

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.