Evidence map›Paper›PMID 41623825›Full record

ArticleBioinformation2025

Molecular docking analysis of IL-6 and TNF-alpha with phytochemicals from

Nivetha G, Sri Sakthi Logisha M, Subha V, Sowmiya K, Muthukumar N J, Mahalakshmi V

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioinformation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nivetha GDepartment of Varmam Maruthuvam, National Institute of Siddha, the Tamil Nadu Dr. MGR Medical University, Chennai, India.
Sri Sakthi Logisha MDepartment of Sirappu Maruthuvam, National Institute of Siddha, the Tamil Nadu Dr. MGR Medical University, Chennai, India.
Subha VResidential Medical Officer, National Institute of Siddha, Chennai, India.
Sowmiya KConsultant, Aaruthra Siddha Varmam Clinic, Vadapalani, Chennai, India.
Muthukumar N JCentral Council for Research in Siddha, the Tamil Nadu Dr. MGR Medical University, Chennai, India.
Mahalakshmi VDepartment of Siddhar Yoga Maruthuvam, National Institute of Siddha, the Tamil Nadu Dr. MGR Medical University, Chennai, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoarthritis (OA) is a degenerative musculoskeletal disorder marked by progressive cartilage degradation, synovial inflammation and subchondral bone remodeling, driven by pro-inflammatory mediators such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α). While non-steroidal anti-inflammatory drugs (NSAIDs) remain the standard treatment, their long-term use is constrained by adverse effects, necessitating safer, multi-targeted therapeutic alternatives.

Indexed as

ADMEIL-6 (Interleukin-6) And TNF-Alpha (Tumor Necrosis Factor-Alpha)molecular dockingNilavaagai Kiyazhamosteoarthritisphytocomponents

Identifiers

PMID41623825
PMCPMC12859337

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.