Evidence map›Paper›PMID 41623809›Full record

ArticleBioinformation2025

Potential use of liquid biopsy in diagnosing oral malignancies.

Timbadiya Vijaykumar Mansukhbhai, Madhvika Patidar, Manjiri Chakor, Dakshayani Vijay Patil, Pawan Rebello, Gatha Mohanty, Rashmi Laddha

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioinformation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Timbadiya Vijaykumar MansukhbhaiDepartment of Oral Pathology and Microbiology, Rishiraj College of Dental Science and Research Centre, Bhopal, Madhya Pradesh, India.
Madhvika PatidarDepartment of Oral Pathology and Microbiology, Government College of Dentistry, Indore, Madhya Pradesh, India.
Manjiri ChakorDepartment of Oral and Maxillofacial Surgery, RD Dental College & Research Center, Nagpur, Maharashtra, India.
Dakshayani Vijay PatilDepartment of Oral & Maxillofacial Pathology, Hazaribag College of Dental Sciences and Hospital, Hazaribagh, Jharkhand, India.
Pawan RebelloDepartment of Oral & Maxillofacial Pathology & Oral Microbiology, Sardar Patel Postgraduate Institute of Dental and Medical Sciences, Lucknow, Uttar Pradesh, India.
Gatha MohantyDepartment of Periodontics and Oral Implantology, Institute of Dental Science, Siksha 'O' Anusandhan Deemed to be University, Bhubaneswar, Odisha, India.
Rashmi LaddhaDepartment of Periodontology, RR Kambe Dental College and Hospital, Akola, Maharashtra, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liquid biopsy is a minimally invasive method with strong potential for detecting and monitoring oral cancers. By analyzing ctDNA, CTCs, exosomes and other tumor-derived biomarkers, it enables early detection, prognosis and treatment monitoring. Unlike tissue biopsy, it allows repeated sampling to track tumor burden and genetic changes over time. In oral squamous cell carcinoma, studies show good sensitivity and specificity for detecting mutations, methylation and protein markers. However, standardization, biomarker validation and cost-effectiveness remain challenges for clinical use.

Indexed as

circulating tumor cellscirculating tumor DNAearly cancer detectionexosomesLiquid biopsynon-invasive diagnosticsoral malignanciesoral squamous cell carcinoma

Identifiers

PMID41623809
PMCPMC12859268

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.