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Obstructive Sleep Apnea in Head and Neck Cancer Survivors: A Systematic Review and Meta-Analysis.
Review in OTO open. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: The purpose of this study is to perform the first systematic review and meta-analysis examining the risks of obstructive sleep apnea in head and neck cancer survivors with the goal of determining if there is a statistically significant increase in the risk of obstructive sleep apnea after treatment for head and neck cancer. Additionally, we sought to determine if specific treatment modalities are associated with an increased risk of obstructive sleep apnea. Data Sources: A comprehensive literature search was performed using Embase, Ovid MEDLINE, Web of Science, and Ovid All EBM Reviews. Review Methods: Included studies performed polysomnography in head and neck cancer patients before and/or after treatment. Random effects meta-analyses were used to estimate overall prevalences of obstructive sleep apnea and apnea-hypopnea index change before versus after head and neck cancer treatment. Results: The literature search returned 575 articles for initial review, of which 16 articles met criteria for inclusion and meta-analysis (419 participants). The mean obstructive sleep apnea prevalence in head and neck cancer survivors was 83.7%. Mean prevalence before treatment was 79.9% [70.0%, 88.3%] and after treatment was 88.7% [82.3%, 94.0%]. In random effects meta-analysis, patients had a statistically significant increase in apnea-hypopnea index of 4.28 [0.46, 8.09] after treatment. Conclusion: There is a high prevalence of obstructive sleep apnea in head and neck cancer survivors independent of treatment modality. Therefore, we propose that all head and neck cancer survivors undergo routine validated screening for obstructive sleep apnea.
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