ArticleBioMed research international2026
Evaluation of miRNA Expression in Pediatric Cirrhosis Caused by BA and PFIC.
Article in BioMed research international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Evaluation of miRNA Expression in Pediatric Cirrhosis Caused by BA and PFIC.BioMed research international · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Liver cirrhosis is one of the most common causes of death for pediatric patients with cholestasis. Because microRNA (miRNA) plays a part in the pathogenesis of the disease, comparing the changes in miRNA expression in cholestatic patients with liver cirrhosis could be helpful for therapeutic or prognostic purposes. miRNA levels in cirrhotic pediatric patients with progressive familial intrahepatic cholestasis (PFIC) and biliary atresia (BA) were studied in this research to comprehend the molecular distinctions and the significance of miRNA regulation in fibrosis and liver cirrhosis. Blood samples were collected from 43 PFIC patients and 84 BA patients, all of whom were confirmed to have liver cirrhosis. The in-house SYBR Green RT-qPCR techniques were established to assess the variations in the expressions of 12 miRNAs. Utilizing bioinformatics tools, the gene targets of the studied miRNAs were examined. Patients' expression of 12 miRNAs was higher than that of the healthy group. However, there was a notable distinction between the miRNAs in PFIC and BA. The levels of miR-34, miR-155, miR-199, miR-200b, and miR-222 were significantly higher in BA than in PFIC. PFIC showed a significantly higher level of miR-223 than BA. The predictive importance of distinct miRNAs in both diseases was revealed by the AUC values. In BA, miR-222 was associated with both liver transplantation and the PELD score. Death was correlated with miR-21, miR-155, miR-199, and miR-200 in BA and miR-34 in PFIC. The analysis showed the significance of the connection between miRNA expression and PI3K/Akt and TGF-
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