Evidence map›Paper›PMID 41623668›Full record

ReviewBrain, behavior, & immunity - health2026

"The emerging role of lymphocytes in post-stroke inflammation: A treatable target and review of current pharmacological evidence in humans".

A Papageorgiou, D Chatzistefanidis, M Nikolakea, N-R Karela, M Gkrampovari, K Lantavos, D Bartzi, L Traikov, S Markoula

Abstract readReview
In one paragraph

Review in Brain, behavior, & immunity - health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

A PapageorgiouUniversity of Ioannina, Medical School, Department of Neurology, Greece.
D ChatzistefanidisUniversity of Ioannina, Medical School, Department of Neurology, Greece.
M NikolakeaNational and Kapodistrian University of Athens, Medical School, Greece.
N-R KarelaNational and Kapodistrian University of Athens, Medical School, Greece.
M GkrampovariNational and Kapodistrian University of Athens, Medical School, Greece.
K LantavosMedical University-Sofia, Department of Medical Physics and Biophysics, Bulgaria.
D BartziNational and Kapodistrian University of Athens, Medical School, Greece.
L TraikovMedical University-Sofia, Department of Medical Physics and Biophysics, Bulgaria.
S MarkoulaUniversity of Ioannina, Medical School, Department of Neurology, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute ischemic stroke is one of the leading causes of mortality and morbidity worldwide. The underlying inflammation process following the ischemic event arises as an important factor of great therapeutic interest. Recent research has showcased the roles of B- and T-lymphocytes in the acute post-stroke period, with various types of lymphocytes affecting differently the clinical outcome of the patient. Herein, we reviewed the literature and discussed the functional role of various subpopulations of lymphocytes in recovery and repair of the ischemic tissue as well as their influence on the final outcome of the patient. Additionally, we searched the literature regarding current knowledge on various drugs possibly affecting neuroinflammation or exhibiting a neuroprotective role in the acute post-stroke period.

Indexed as

InflammationLymphocytesPharmacological approachesStroke

Identifiers

PMID41623668
PMCPMC12856344

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.