ArticleFrontiers in microbiology2025
Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
9 authors.
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Abstract
Introduction: Schizophrenia (SCZ) and bipolar disorder (BD) are severe psychiatric disorders with overlapping clinical manifestations and shared biological mechanisms. Growing evidence implicates the gut microbiota in neuroimmune and metabolic regulation, suggesting a potential role in the pathophysiology and heterogeneity of psychiatric disorders. Methods: In this comparative study, fecal samples were collected from 43 patients with SCZ, 19 patients with BD, and 40 healthy controls (HC). Gut microbial composition was profiled using 16S rRNA gene sequencing. Microbial diversity, taxonomic composition, and predicted functional pathways were analyzed, and associations between key taxa and clinical symptom dimensions were assessed. Results: Both SCZ and BD patients exhibited significantly reduced microbial diversity and distinct alterations in gut microbial composition compared with HC. SCZ was characterized by a pro-inflammatory microbial profile, whereas BD showed dysbiosis associated with metabolic disturbances, particularly pathways related to lipid metabolism and obesity susceptibility. Functional prediction revealed downregulation of fatty acid biosynthesis and metabolism pathways, along with selective upregulation of antioxidant-related pathways in SCZ. Notably, Discussion: These findings suggest that Parabacteroides, particularly
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