Evidence map›Paper›PMID 41623638›Full record

ArticleFrontiers in microbiology2025

The human plasma anellome exhibits age- and sex-dependent patterns with links to cardiometabolic health in older adults.

Yakhouba Kane, Yingying Ma, Beibei Yan, Xiuli Zhao, Ting Ge, Yanpeng Li, Le Cao, Min Zhang, Zhenzhou Wan, Ting Zhang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yakhouba KaneShanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Yingying MaShanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Beibei YanMedical Laboratory, Taizhou Fourth People's Hospital, Taizhou, Jiangsu, China.
Xiuli ZhaoMedical Laboratory, Taizhou Fourth People's Hospital, Taizhou, Jiangsu, China.
Ting GeGut Microbiota and Metabolic Research Center, Institute of Pediatric Infection, Immunity and Critical Care Medicine, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Yanpeng LiShanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Le CaoShanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Min ZhangShanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Zhenzhou WanMedical Laboratory, Taizhou Fourth People's Hospital, Taizhou, Jiangsu, China.
Ting ZhangGut Microbiota and Metabolic Research Center, Institute of Pediatric Infection, Immunity and Critical Care Medicine, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Chiyu ZhangShanghai Public Health Clinical Center, Fudan University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The human plasma virome is dominated by anelloviruses which are increasingly associated with several clinical conditions including among others HIV-1, COVID-19, autoimmune diseases, and cardiovascular and metabolic diseases. Due to their high genetic divergence, most studies investigated human anellome at broad family or genus level. These approaches obscure the contributions of specific anellovirus species to clinical conditions. We conducted plasma metagenomics in 218 individuals from young (0-16 years) and old (63-100 years) cohorts to resolve the anellome at the species level and examine its patterns across age, sex, and associations with cytokines and cardiometabolic outcomes. Older adults exhibited near-universal anellovirus detection and significantly higher abundance compared with youth. Species-specific analysis revealed that

Indexed as

anellovirusescardiometabolic diseasescytokinesHERV-Kmetagenomicsplasma virome

Identifiers

PMID41623638
PMCPMC12852332

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.