ArticleFrontiers in microbiology2025
Diagnostic value of combined detection of cryptococcal antigen in serum and lung puncture fluid using lateral flow assay for diagnosing pulmonary cryptococcosis: a single-center prospective study.
Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Exhaled breath condensate metabolomics reveals inflammation-associated metabolic alterations and metabolites with possible relevance to virulence-related processes in pulmonary cryptococcosis.Frontiers in cellular and infection microbiology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To evaluate the diagnostic value of the combined detection of cryptococcal antigen (CrAg) in the serum and lung puncture fluid (LPF) using a lateral flow assay (LFA) in patients with pulmonary cryptococcosis (PC). Methods: Patients with suspected PC were prospectively enrolled between June 2023 and July 2025 and underwent the IMMY CrAg LFA (Immuno-Mycologics, Norman, OK, United States) of serum and LPF specimens. Conventional fungal cultures were performed simultaneously and the diagnostic efficiencies of these methods for PC were compared. Results: Samples were obtained from 167 patients, 33 with PC and 134 without PC. Among patients with PC, the sensitivity of serum CrAg testing was 75.8% [95% confidence interval (CI), 61.1-90.4%; 25/33] and that of LPF CrAg testing was 90.9% (95% CI, 81.1-100%; 30/33). The combination of serum and LPF testing increased the overall sensitivity of CrAg testing to 97.0% (95% CI, 91.2-100%; 32/33). The sensitivity, accuracy, and negative predictive value (NPV) of LPF culture were significantly lower than those of serum CrAg detection ( Conclusion: Serum CrAg testing has superior sensitivity and accuracy compared to the conventional cryptococcal culture method using LPF, and CrAg testing of LPF samples further enhances diagnostic sensitivity. Moreover, detecting CrAg in serum and LPF specimens together provides high sensitivity and specificity, which significantly improves the diagnostic efficiency of PC.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.