ArticleFrontiers in microbiology2025
HIV-1 drug resistance and genetic clustering among ART-treated individuals with virologic failure in Aksu, China.
Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Aksu Prefecture is among the regions most heavily affected by HIV-1 in China, yet data on acquired drug resistance (ADR) among antiretroviral therapy (ART)-treated individuals with virologic failure remain limited. This study aimed to characterize the prevalence, mutation patterns, and genetic clustering of drug resistance mutations (DRMs) in Aksu. Methods: We conducted a retrospective study among ART-treated individuals with virologic failure in Aksu Prefecture from 2022 to 2023. HIV-1 pol sequences were obtained from 675 individuals to identify DRMs. Genetic networks were constructed to assess clustering among individuals harboring DRMs ( Results: The prevalence of ADR was 56.9% (384/675). CRF07_BC was the predominant subtype (97.6%). The most common DRMs were K103N/S (60.7%), M184V/I (27.3%), G190A/E/S (11.3%), and E138A/K/Q/G (10.8%), conferring high-level resistance mainly to lamivudine (3TC), efavirenz (EFV), and nevirapine (NVP). K65R was more frequent among individuals receiving TDF + 3TC + EFV/NVP, whereas Q58E was more common among those receiving LPV/r + 3TC + TDF/AZT (both Conclusion: HIV-1 ADR remains highly prevalent among ART-treated individuals with virologic failure in Aksu. Extensive resistance to NNRTIs was observed, whereas susceptibility to LPV/r was largely preserved. The clustering of DRMs underscores the importance of molecular surveillance for guiding targeted interventions. These findings support accelerating access to effective second-line regimens, strengthening pretreatment resistance surveillance, and prioritizing adherence support among central individuals with high viral loads.
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