Evidence map›Paper›PMID 41623573›Full record

ArticleJournal of cellular signaling2025

A Newly Characterized, Two BRCT Domain-Containing Isoform of PAX-Interacting Protein (PTIP) Generated via Frame Shift and Alternative Pre-mRNA Splicing.

Ching-Jung Huang, Chuan Li, Danyang Yu, Hyein Cho, Kangsan Kim, Y Jessie Zhang, Daechan Park, Haley O Tucker

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular signaling, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ching-Jung HuangDepartment of Biology, Arts and Sciences, New York University in Shanghai, Shanghai 200122, China.
Chuan LiMolecular Biosciences, University of Texas at Austin, 1 University Station A5000, Austin, TX 78712, USA.
Danyang YuDepartment of Biology, Arts and Sciences, New York University in Shanghai, Shanghai 200122, China.
Hyein ChoDepartment of Molecular Science and Technology, Advanced College of Bio-Convergence Engineering, Ajou University 206 Worldcup-ro, Yeongtong-gu, Suwon 16499, South Korea.
Kangsan KimMolecular Biosciences, University of Texas at Austin, 1 University Station A5000, Austin, TX 78712, USA.
Y Jessie ZhangMolecular Biosciences, University of Texas at Austin, 1 University Station A5000, Austin, TX 78712, USA.
Daechan ParkDepartment of Molecular Science and Technology, Advanced College of Bio-Convergence Engineering, Ajou University 206 Worldcup-ro, Yeongtong-gu, Suwon 16499, South Korea.
Haley O TuckerMolecular Biosciences, University of Texas at Austin, 1 University Station A5000, Austin, TX 78712, USA.

Funding

VIRAL TRANSACTIVATIONP01CA013106 · NCI · COLD SPRING HARBOR LABORATORY · PI William Richard McCombie · 1985 to 2026
$116.8M
MAR MEDIATED GENETIC SWITCH FOR IGH ENHANCER CONTROLR01CA031534 · NCI · UNIVERSITY OF TEXAS SW MED CTR/DALLAS · PI TUCKER, HALEY O · 1985 to 2012
$2.9M
Elucidating the SCP4 pathway as a multi-catalytic signaling dependency in acute myeloid leukemiaR01CA281106 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Christopher Vakoc, Yan Jessie Zhang · 2023 to 2026
$2.9M
Deciphering the phosphorylation pattern of RNA polymerase II for eukaryotic transcriptionR35GM148356 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI Yan Jessie Zhang · 2023 to 2026
$2.3M
NCI NIH HHS P01 CA013106NCI NIH HHS R01 CA031534NCI NIH HHS R01 CA281106NIGMS NIH HHS R35 GM148356
6 · The paper itself

Abstract

In an effort to clone polyglutamine-rich factors from activated B lymphocytes of mice, we discovered and describe here a previously uncharacterized isoform of PTIP/PAXIP1. By virtue of a two-nucleotide frameshift followed by alternative pre-mRNA splicing, this shorter isoform of 576 amino acids (termed PTIP576) retained only the two central BRCT domains of previously characterized PTIP and encodes a unique and structurally disordered 50 residue C-terminus. PTIP576 is expressed primarily in nuclei of progenitor and activated mature B lymphocytes. Transgenic overexpression of PTIP576 in murine B and T cells led to increased lineages of bone marrow B cells and thymocyte CD4 T cells. We conclude by addressing potential functions of PTIP576 resulting from the relatively unique mechanism by which it is engendered.

Indexed as

B cellsBreast cancer C-TerminalLymphocytesPlasma cells

Identifiers

PMID41623573
PMCPMC12857844

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.