Evidence map›Paper›PMID 41623554›Full record

ArticleTransboundary and emerging diseases2026

Phorbol Myristate Acetate Inhibits Senecavirus A Replication by Activating IKBKE-Mediated IFN Pathway and NF-κB Signal.

Junfang Yan, Yanni Gao, Chengyi Guo, Yubei Dong, Ping Jiang, Juan Bai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transboundary and emerging diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Junfang YanKey Laboratory of Animal Diseases Diagnostic and Immunology, Ministry of Agriculture, MOE International Joint Collaborative Research Laboratory for Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China, njau.edu.cn.ORCID https://orcid.org/0009-0000-4021-1695
Yanni GaoKey Laboratory of Animal Diseases Diagnostic and Immunology, Ministry of Agriculture, MOE International Joint Collaborative Research Laboratory for Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China, njau.edu.cn.
Chengyi GuoKey Laboratory of Animal Diseases Diagnostic and Immunology, Ministry of Agriculture, MOE International Joint Collaborative Research Laboratory for Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China, njau.edu.cn.
Yubei DongKey Laboratory of Animal Diseases Diagnostic and Immunology, Ministry of Agriculture, MOE International Joint Collaborative Research Laboratory for Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China, njau.edu.cn.
Ping JiangKey Laboratory of Animal Diseases Diagnostic and Immunology, Ministry of Agriculture, MOE International Joint Collaborative Research Laboratory for Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China, njau.edu.cn.ORCID https://orcid.org/0000-0003-2812-3101
Juan BaiKey Laboratory of Animal Diseases Diagnostic and Immunology, Ministry of Agriculture, MOE International Joint Collaborative Research Laboratory for Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China, njau.edu.cn.ORCID https://orcid.org/0009-0000-4979-3724

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Senecavirus A (SVA) is an emerging picornavirus causing vesicular disease indistinguishable from foot-and-mouth disease virus (FMDV). So far, there are no commercial vaccines and effective therapeutic drugs against SVA infection in China. Here, a library of 112 compounds were screened, and we found that phorbol myristate acetate plays an antagonistic role in the early stage of SVA infection. And phorbol 12-myristate 13-acetate (PMA) upregulates the expression of IKBKE, and activates IFN pathway and NF-κB signal. However, the PMA-mediated detrimental effect on SVA is reversed in IKBKE-deficient cells or when the NF-κB pathway blocked by BAY-117082, implying that IKBKE is the target for the antiviral effect of PMA. Additionally, PMA possesses antiviral effect on multiple RNA viruses, including porcine epidemic diarrhea virus (PEDV), porcine reproductive and respiratory syndrome virus (PRRSV), and encephalomyocarditis virus (EMCV). Overall, our findings offer that PMA inhibits SVA replication by activating IKBKE-mediated IFN pathway and NF-κB signal. And it might be a promising candidate for further broad-spectrum therapeutic development.

Indexed as

Antiviral AgentsI-kappa B KinaseInterferonsNF-kappa BPicornaviridae InfectionsTetradecanoylphorbol AcetateVirus ReplicationAnimalsPicornaviridaeSignal TransductionAntiviral AgentsI-kappa B KinaseInterferonsNF-kappa BTetradecanoylphorbol AcetateIKBKEimmune responsephorbol myristate acetateSenecavirus A

Identifiers

PMID41623554
PMCPMC12860142

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.