Evidence map›Paper›PMID 41623492›Full record

ArticleiScience2026

Targeting Piezo1 can improve endometrial fibrosis by inhibiting ferroptosis in endothelial cells.

Huan Yang, Chaoxun Dou, Ruohong Pan, Yaoyao Xu, Kaixuan Zeng, Jiayu Huang, Lu Sun, Yuqing Yao, Jiancheng Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Huan YangScientific Research Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen 518107, China.
Chaoxun DouDepartment of Anesthesiology, The third Affiliated hospital of Sun Yat-sen University, Guangzhou 510630, China.
Ruohong PanSchool of Medicine, Sun Yat-sen University, Shenzhen 518107, China.
Yaoyao XuDepartment of Education, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen 518107, China.
Kaixuan ZengSchool of Medicine, Sun Yat-sen University, Shenzhen 518107, China.
Jiayu HuangScientific Research Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen 518107, China.
Lu SunScientific Research Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen 518107, China.
Yuqing YaoScientific Research Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen 518107, China.
Jiancheng WangScientific Research Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen 518107, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intrauterine adhesion (IUA) is a fibrotic disorder characterized by excessive extracellular matrix deposition, leading to menstrual abnormalities, infertility, and recurrent miscarriage, for which effective treatments are lacking. Here, we employed single-cell RNA sequencing to analyze murine IUA models, revealing for the first time a significant reduction in endometrial endothelial cells accompanied by markedly upregulated

Indexed as

cell biologymechanobiologytranscriptomics

Identifiers

PMID41623492
PMCPMC12855580

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.