Evidence map›Paper›PMID 41623472›Full record

ArticleiScience2026

HP1β recruits RING1A to ubiquitinate histone H2A for BRCA1-mediated resection of double-stand breaks.

Vijaya Charaka, Raj K Pandita, Chi-Lin Tsai, Xiaoyan Wang, Sharmista Chakraborty, Kenneth S Ramos, Sandhik Nandi, Fransisca Leonard, Vipin Singh, Partha S Sarkar and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Vijaya CharakaDepartment of Radiation Oncology, The Houston Methodist Research Institute, Houston, TX 77030, USA.
Raj K PanditaDepartment of Radiation Oncology, The Houston Methodist Research Institute, Houston, TX 77030, USA.
Chi-Lin TsaiDepartment of Molecular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Xiaoyan WangDepartment of Molecular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Sharmista ChakrabortyDepartment of Radiation Oncology, The Houston Methodist Research Institute, Houston, TX 77030, USA.
Kenneth S RamosCenter for Genomic and Precision Medicine, Institute of Biosciences and Technology, Texas A&M College of Medicine, Houston, TX 77030, USA.
Sandhik NandiBiophysics and Structural Genomics Division, Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata 700064, India.
Fransisca LeonardDepartment of Radiation Oncology, The Houston Methodist Research Institute, Houston, TX 77030, USA.
Vipin SinghBiophysics and Structural Genomics Division, Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata 700064, India.
Partha S SarkarDepartment of Neurobiology and Department of Neurology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Clayton R HuntDepartment of Radiation Oncology, The Houston Methodist Research Institute, Houston, TX 77030, USA.
John A TainerDepartment of Molecular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Chandrima DasBiophysics and Structural Genomics Division, Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata 700064, India.
Tej K PanditaDepartment of Radiation Oncology, The Houston Methodist Research Institute, Houston, TX 77030, USA.

Funding

Mesoscale and Nanoscale Technologies Integrated by Structures for DNA Repair Complexes (MANTIS-DRC)R35CA220430 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI John A. Tainer · 2018 to 2026
$7.6M
NCI NIH HHS R35 CA220430
6 · The paper itself

Abstract

Efficient DNA double-strand break (DSB) repair by homologous recombination (HR), as initiated by BRCA1 recruitment orchestrated by histone and non-histone proteins, is critical to genome stability, replication, transcription, and cancer avoidance. Here we reveal Heterochromatin Protein1 beta (HP1β) promotes BRCA1 enrichment at DNA DSB sites in gene-rich regions, and this is impaired by HP1β depletion. We find that HP1β is specifically enriched at DSBs within gene-rich regions via its Chromo Shadow Domain (CSD) that interacts with both Chromatin Assembly Factor 1 and the RING1A ubiquitinase component of Polycomb Repressor Complex 1. The resulting protein complex facilitates BRCA1 recruitment by promoting H2A lysine 119 ubiquitination. Collective findings reveal a novel mechanism whereby HP1β interactions, mediated through its CSD of HP1β interaction with RING1A, promotes H2AK119 ubiquitination to facilitate BRCA1 recruitment and orchestrate efficient HR and CtIP-dependent DNA resection at DSB sites in gene-rich active chromatin.

Indexed as

BiochemistryMolecular biology

Identifiers

PMID41623472
PMCPMC12856345

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.