ArticleiScience2026
Self-collected finger-prick blood for gene expression profiling: Unveiling early immune responses in mild COVID-19.
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04356495 (Randomized Trial to Evaluate the Safety and Efficacy of Outpatient Treatments to Reduce the Risk of Worsening in Individuals With COVID-19 With Risk Factors), which is not on this map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized Trial to Evaluate the Safety and Efficacy of Outpatient Treatments to Reduce the Risk of Worsening in Individuals With COVID-19 With Risk Factors (COVERAGE France)
Who cites it
2 citing papers in PubMed.
- SARS-CoV-2 mRNA XBB1.5 vaccine immunogenicity in kidney transplant recipients.Virology journal · 2026Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Whole-blood gene expression analysis is essential for understanding molecular host responses, yet its use typically relies on venous sampling, limiting feasibility for frequent and remote monitoring. In an ancillary study of the COVERAGE France platform trial (NCT04356495), which enrolled at-risk outpatients with mild coronavirus disease 2019 (COVID-19) monitored at home, we compared transcriptomic profiles obtained from paired venous blood (Tempus tubes) and ultralow-volume, self-collected finger-prick capillary samples. We observed moderate to good concordance at the individual gene level and excellent agreement at the gene-set level between the two sampling approaches. High-frequency finger-prick sampling enabled daily resolution of immune dynamics, revealing early interferon responses, sustained neutrophil activation, and evolving erythroid and inflammatory signatures during the initial phase of mild COVID-19. These results demonstrate that finger-prick sampling is a feasible and reliable approach for at-home transcriptomic profiling, offering a powerful tool for longitudinal immune monitoring and advanced clinical research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.