Evidence map›Paper›PMID 41623454›Full record

ArticleiScience2026

Association between immune cells and multiple cancers: Insights from Mendelian randomization and gene-based analysis.

Mingshuang Tang, Huijie Cui, Xueyao Wu, Yutong Wang, Xunying Zhao, Rong Xiang, Jinyu Xiao, Lin Chen, Yanqiu Zou, Yunjie Liu and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Mingshuang TangDepartment of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.
Huijie CuiDepartment of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.
Xueyao WuDepartment of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.
Yutong WangDepartment of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.
Xunying ZhaoDepartment of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.
Rong XiangDepartment of Epidemiology and Health Statistics, School of Public Health, Southwest Medical University, Luzhou, Sichuan, China.
Jinyu XiaoDepartment of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.
Lin ChenDepartment of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.
Yanqiu ZouDepartment of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.
Yunjie LiuDepartment of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.
BoWen LeiDepartment of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.
Xiaofeng MaDepartment of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.
Di ZhangDepartment of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.
Mengyu FanDepartment of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.
Jiayuan LiDepartment of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.
Xia JiangDepartment of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.
Ben ZhangDepartment of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To investigate the roles of immune cells in cancer, we conducted Mendelian randomization (MR) analyses of 731 immune cells and 16 site-specific cancers, alongside gene-based and enrichment analyses. MR identified 79 significant associations (46 protective, 33 risk-enhancing). Key findings include BAFF-R on B cells lowering melanoma risk, and CD27 on B cells increasing lung cancer risk. Associations were also observed with breast, ovarian, cervical, and other cancers, but no significant association was found with oral cavity or pancreatic cancers. Gene-based analysis revealed 61 shared genes between immune cells and cancers. 56 genes were associated with prostate cancer, 30 with lung cancer, three with breast cancer, two with cervical cancer, and one with melanoma. Interestingly, several prostate cancer-associated genes were also associated with breast, cervical, and lung cancers. These findings suggest potential biological mechanisms linking immune cells to cancer development and progression, highlighting the complex role of the immune system in cancer.

Indexed as

Health sciences

Identifiers

PMID41623454
PMCPMC12857361

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.