ArticleJournal of research in medical sciences : the official journal of Isfahan University of Medical Sciences2025
Propofol alone versus midazolam plus propofol for sedation in outpatient endoscopic procedures: A randomized controlled trial.
Article in Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Propofol and midazolam are the most commonly used sedatives in endoscopic procedures. The purpose of this study was to compare these two sedation regimens prescribed during outpatient endoscopy and colonoscopy procedures. Materials and Methods: In this randomized clinical trial, 242 low-risk anesthesia patients (American society of anesthesilogist [ASA] I-II) referred to the endoscopy and colonoscopy ward of Al-Zahra Hospital, Isfahan, from January to June 2025, were studied. Patients were divided into two groups: sedation with propofol (P) and midazolam + propofol (M + P). After the collection of data, they were analyzed through SPSS version 18 software. Results: In the procedures, the P group had lower systolic blood pressure (BP) readings ( Conclusion: Propofol supplementation with midazolam enhanced some of the physiological parameters, like RR and systolic BP stability. However, it was at the expense of prolonged recovery and increased pain experience. Propofol alone ensured quicker recovery and greater analgesia but needed increased monitoring as a result of larger physiological excursions.
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