Evidence map›Paper›PMID 41623402›Full record

ArticleBMJ neurology open2026

18F-DPA-714 PET/MRI reveals early and widespread neuroinflammation in sporadic Creutzfeldt-Jakob disease: a case report.

Zhuoying Zhu, Qing Huang, Sheng Chen, Qinming Zhou

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Article in BMJ neurology open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Zhuoying ZhuDepartment of Neurology, the Second Affiliated Hospital of Jiaxing University, Jiaxing, People's Republic of China.
Qing HuangDepartment of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Sheng ChenDepartment of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.ORCID https://orcid.org/0000-0001-7428-7153
Qinming ZhouDepartment of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.ORCID https://orcid.org/0000-0001-6211-0588

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Creutzfeldt-Jakob disease (CJD) is a fatal neurodegenerative disorder caused by prion proteins, with microglial activation being a key immunopathological feature. This case report demonstrates the application of Case presentation: A 57-year-old woman presented with progressive rapid cognitive decline and behavioural change. MRI revealed restricted diffusion within the patchy cortical ribbon of bilateral frontal, parietal, occipital lobes and right caput nuclei caudate. Lumbar puncture revealed positive 14-3-3 protein and robustly positive real-time quaking-induced conversion assay, fulfilling the diagnostic criteria for definite sCJD. Conclusions: This is the first reported case of sCJD evaluated with

Indexed as

CREUTZFELDT-JAKOB DISEASEDEMENTIAPET, FUNCTIONAL IMAGING

Identifiers

PMID41623402
PMCPMC12853426

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.