ArticleThe World Allergy Organization journal2026
Dupilumab in real-world pediatric asthma: Enhanced control and quality of life for children and caregivers.
Article in The World Allergy Organization journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Dupilumab has demonstrated therapeutic benefits and improved quality of life (QoL) in children with uncontrolled asthma. This real-world study-the first in a Latin-American pediatric population-evaluated its impact on asthma control and QoL in children with moderate-to-severe uncontrolled type 2 asthma and their caregivers. Methods: We conducted a retrospective observational study of patients aged 4-16 years with moderate-to-severe uncontrolled type 2 asthma (blood eosinophils ≥150 cells/μL or fractional exhaled nitric oxide ≥20 ppb). Eleven patients received dupilumab and 12 received conventional inhaled therapy, with 52-week follow-up. Asthma control was assessed using the 7-item Asthma Control Questionnaire interviewer-administered version (ACQ-7-IA). QoL was evaluated using the Pediatric Asthma Quality of Life Questionnaire interviewer-administered version (PAQLQ[S]-IA) and the Pediatric Asthma Caregiver's Quality of Life Questionnaire (PACQLQ). The primary endpoints were changes in ACQ-7-IA, PAQLQ(S)-IA, and PACQLQ scores, and the proportion achieving clinically significant improvement (≥0.5 points). Results: Dupilumab significantly improved ACQ-7-IA scores from week 4, sustained through week 52 (least squares mean difference -0.44, 95% CI -0.59 to -0.30; p < 0.001). At week 52, 86% of dupilumab-treated patients achieved clinically significant improvement versus 75% with conventional therapy (p = 0.041). Well-controlled asthma (ACQ-7-IA ≤0.75) was achieved in 73% versus 36% (p < 0.003). Dupilumab also improved PAQLQ(S)-IA and PACQLQ scores from week 24, with 100% of patients and caregivers achieving clinically significant improvement at week 52. Conclusions: In Latin-American children with moderate-to-severe type 2 asthma, dupilumab was associated with early and sustained improvements in asthma control and QoL for both patients and caregivers, supporting its role as an effective therapeutic option in real-world pediatric practice.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.