Evidence map›Paper›PMID 41623394›Full record

ArticlePeerJ2026

Integrative analysis for identification of key miRNA-mRNA regulatory axes in esophageal cancer and preliminary validation of the regulatory role of miR-15b-5p/

Wenyuan Hong, Chaoyang Xia, Gao Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Research progress on BTG2 in non‑tumor diseases (Review).International journal of molecular medicine · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Wenyuan Hong *Department of Thoracic Surgery, Hainan General Hospital (Affiliated Hainan Hospital of Hainan Medical University), Haikou, China.
Chaoyang Xia *Department of Thoracic Surgery, Hainan General Hospital (Affiliated Hainan Hospital of Hainan Medical University), Haikou, China.
Gao LiDepartment of Thoracic Surgery, Hainan General Hospital (Affiliated Hainan Hospital of Hainan Medical University), Haikou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Esophageal cancer (ESCA), a leading cause of cancer-related mortality, lacks reliable biomarkers for early detection and prognosis. Dysregulated microRNAs (miRNAs) have emerged as pivotal regulators of tumor progression, yet their context-specific roles and interactions with target genes in ESCA remain underexplored. Methods: Multi-omics data from The Cancer Genome Atlas-esophageal cancer (TCGA-ESCA) and Gene Expression Omnibus (GEO) datasets were integrated to identify differentially expressed miRNAs and mRNAs. A miRNA-mRNA regulatory network was constructed using FunRich and validated through functional assays, including dual-luciferase reporter, quantitative reverse transcription polymerase chain reaction (qRT-PCR) and Results: We identified 1,131 differentially expressed mRNAs and 69 miRNAs in ESCA. The miR-15b-5p/ Conclusions: The miR-15b-5p/

Indexed as

Esophageal NeoplasmsGene Expression Regulation, NeoplasticImmediate-Early ProteinsMicroRNAsRNA, MessengerTumor Suppressor ProteinsBiomarkers, TumorCell Line, TumorCell MovementCell ProliferationGene Regulatory NetworksHumansPrognosisBiomarkers, TumorBTG2 protein, humanImmediate-Early ProteinsMicroRNAsMIRN15 microRNA, humanRNA, MessengerTumor Suppressor ProteinsEsophageal cancerFunctional genomicsmiR-15b-5p/BTG2miRNA-mRNA networkPrognostic biomarker

Identifiers

PMID41623394
PMCPMC12860276

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.