ArticleHealth science reports2026
Evaluating the Effect of Therapeutic Antibiotics in Prosthetic Joint Infections Culturing: A Narrative Review.
Article in Health science reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Metagenomic and Targeted Next-Generation Sequencing in Infectious Disease Diagnostics: Current Applications, Challenges, and Future Perspectives.Diagnostics (Basel, Switzerland) · 2026Review
- Evaluating the Effect of Therapeutic Antibiotics in Prosthetic Joint Infections Culturing: A Narrative Review.Health science reports · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aims: One of the important complications of knee and hip replacement arthroplasty is prosthetic joint infection (PJI), which is usually accompanied by negative culture that leads to severe consequences compared to positive ones. This study aims to evaluate the arbitrary use or mistreatment of antibiotics for therapeutic purposes before the final diagnosis of PJI and its effect on the culture result and the process of diagnosis and treatment of these infections. Method: A comprehensive search was performed in PubMed/MEDLINE, EMBASE, and Scopus using the following keywords: "PJI," "Antibiotic therapy," "False negative," and "Culture." We included clinical trials, cohort, case-control, and cross-sectional studies written in English. Results: Among the nine reviewed studies, all mentioned the therapeutic use of antibiotics as an important reason for negative culture results in PJI. Five studies examined the minimum recommended time for discontinuing antibiotic therapy, which varied from 4 days to 3 months. Four studies evaluated the type and dosage of antibiotics, and one study discussed the effect of antibiotics on tissue-infecting microorganisms. Conclusion: Using antibiotics for therapeutic purposes is the leading cause of false-negative cultures in joint prosthesis infections, which reduces the sensitivity of the culture in different ways, such as bacterial biofilm formation. Discontinuing antibiotics at least 2 weeks before sampling can help increase the sensitivity of the culturing. More studies should be done on other factors related to the effect of antibiotics on culture results, including the type of antibiotic and microorganism. With the available data, it can only be said that beta-lactams are the most common antibiotics used as therapeutic agents, leading to negative culture results. According to the Al-Mayahi study, therapeutic antibiotics increase the possibility of non-fermenting Gram-negative bacteria growth.
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Registered trials
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