Evidence map›Paper›PMID 41623180›Full record

ArticleThe Journal of clinical investigation2026

Luspatercept ameliorates disease phenotype and complications in the Townes mouse model of sickle cell disease.

Maiko Sezaki, Tian Li, Mingzhe Pan, Zhihong Wang, Jie Bai, Justin G Horowitz, Julia Z Xu, Gang Huang

Abstract read
In one paragraph

Article in The Journal of clinical investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Maiko SezakiDepartment of Cell Systems and Anatomy, UT Health San Antonio, San Antonio, Texas, USA.
Tian LiDepartment of Cell Systems and Anatomy, UT Health San Antonio, San Antonio, Texas, USA.
Mingzhe PanDepartment of Cell Systems and Anatomy, UT Health San Antonio, San Antonio, Texas, USA.
Zhihong WangDepartment of Hematology, Fujian Provincial Hospital, Fuzhou, China.
Jie BaiDepartment of Cell Systems and Anatomy, UT Health San Antonio, San Antonio, Texas, USA.
Justin G HorowitzDepartment of Pharmacy Services, UT Health San Antonio MD Anderson Cancer Center, San Antonio, Texas, USA.
Julia Z XuDivision of Hematology/Oncology, Department of Medicine, University of Pittsburgh, Pennsylvania, USA.
Gang HuangDepartment of Cell Systems and Anatomy, UT Health San Antonio, San Antonio, Texas, USA.

Funding

TISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Lei Zheng · 1991 to 2026
$59.1M
The Role of HIF1A-DNMT3A axis in AML1/ETO-Driven Acute MyelogenousLeukemiaR01CA248019 · NCI · UNIVERSITY OF MINNESOTA · PI LIU, SHUJUN · 2021 to 2025
$3.2M
Role of an Aberrant N6-Methyladenosine-LncRNA Axis in the Development and Maintenance of Drug Resistance through Regulating the Leukemia Stem CellR01CA266256 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI HUANG, GANG, LIU, SHUJUN · 2022 to 2025
$3.0M
NCI NIH HHS P30 CA054174NCI NIH HHS R01 CA248019NCI NIH HHS R01 CA266256
6 · The paper itself

Abstract

Preclinical data demonstrating that luspatercept mitigates vaso-occlusive and anemia-related complications in the Townes sickle cell model provide a strong rationale for its evaluation in SCD patients.

Indexed as

Anemia, Sickle CellImmunoglobulin Fc FragmentsRecombinant Fusion ProteinsActivin Receptors, Type IIAnimalsDisease Models, AnimalHumansMicePhenotypeVaso-Occlusive CrisesActivin Receptors, Type IIImmunoglobulin Fc FragmentsluspaterceptRecombinant Fusion ProteinsHematologyHematopoietic stem cellsImmunology

Identifiers

PMID41623180
PMCPMC12867147

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.