In one paragraphArticle in Circulation. Cardiovascular interventions, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
42 authors.
Takuya MizukamiCardiovascular Center Aalst, AZORG, Aalst, Belgium (T.M., K.I., D.M., K.S., J.S., T. Storozhenko, F.B., E.W., A.W., B.D.B., C.C.).
Kazumasa IkedaCardiovascular Center Aalst, AZORG, Aalst, Belgium (T.M., K.I., D.M., K.S., J.S., T. Storozhenko, F.B., E.W., A.W., B.D.B., C.C.).ORCID 0000-0002-1680-659X Daniel MunhozCardiovascular Center Aalst, AZORG, Aalst, Belgium (T.M., K.I., D.M., K.S., J.S., T. Storozhenko, F.B., E.W., A.W., B.D.B., C.C.).ORCID 0000-0002-8951-4504 Koshiro SakaiCardiovascular Center Aalst, AZORG, Aalst, Belgium (T.M., K.I., D.M., K.S., J.S., T. Storozhenko, F.B., E.W., A.W., B.D.B., C.C.).ORCID 0000-0003-0461-6497 Jeroen SonckCardiovascular Center Aalst, AZORG, Aalst, Belgium (T.M., K.I., D.M., K.S., J.S., T. Storozhenko, F.B., E.W., A.W., B.D.B., C.C.).ORCID 0000-0002-9744-8244 Toshiro ShinkeDivision of Cardiology, Department of Medicine (K.S., T. Shinke), Showa University School of Medicine, Tokyo, Japan.ORCID 0000-0001-7349-7538 Fernando RiveroCardiac Department, Hospital Universitario de La Princesa, IIS-IP, Madrid, Spain (F.R.).ORCID 0000-0002-3676-0277 Antonio Maria LeoneDepartment of Cardiovascular and Pneumological Sciences, Catholic University of the Sacred Heart, Rome, Italy (A.M.L.).
Lokien X van NunenDepartment of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands (L.X.N.).ORCID 0000-0003-4650-5381 William F FearonDivision of Cardiovascular Medicine and Stanford Cardiovascular Institute, Stanford University School of Medicine and VA Palo Alto Health Care System, CA (W.F.F.).ORCID 0000-0003-1799-1368 Evald Høj ChristiansenDepartment of Cardiology, Aarhus University Hospital, Skejby, Denmark (E.H.C.).ORCID 0000-0002-8740-4862 Stephane FournierDepartment of Cardiology, University Hospital of Lausanne, Switzerland (S.F., B.D.B.).ORCID 0000-0002-9422-9521 Liyew DestaDepartment of Cardiology, Karolinska University Hospital, Solna, Stockholm, Sweden (L.D.).ORCID 0000-0002-1950-4159 Andy YongConcord Repatriation General Hospital, University of Sydney, New South Wales, Australia (A.Y.).ORCID 0000-0002-6268-4300 Julien AdjedjDepartment of Cardiology, Arnault Tzanck Institute, Saint Laurent du Var, France (J.A.).ORCID 0000-0002-0902-8347 Javier EscanedInstituto de Investigacion Sanitaria del Hospital Clinico San Carlos and Complutense University, Madrid, Spain (J.E.).ORCID 0000-0003-4932-0112 Frederik M ZimmermannDepartment of Cardiology, Catharina Hospital Eindhoven, the Netherlands (F.M.Z., N.P.).
Tatyana StorozhenkoCardiovascular Center Aalst, AZORG, Aalst, Belgium (T.M., K.I., D.M., K.S., J.S., T. Storozhenko, F.B., E.W., A.W., B.D.B., C.C.).ORCID 0000-0002-9158-2012 Frédéric BouissetCardiovascular Center Aalst, AZORG, Aalst, Belgium (T.M., K.I., D.M., K.S., J.S., T. Storozhenko, F.B., E.W., A.W., B.D.B., C.C.).ORCID 0000-0001-8642-0273 Domenico GalanteCenter of Excellence in Cardiovascular Sciences, Ospedale Isola Tiberina - Gemelli Isola, Rome, Italy (A.M.L., D.G.).ORCID 0000-0002-8663-3225 Bruno R da CostaClinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, United Kingdom (B.R.C.).ORCID 0000-0002-1786-6332 Colin BerrySchool Cardiovascular and Metabolic Health, University of Glasgow, United Kingdom (C.B., D.C.).ORCID 0000-0002-4547-8636 Damien CollisonSchool Cardiovascular and Metabolic Health, University of Glasgow, United Kingdom (C.B., D.C.).ORCID 0000-0002-3531-0872 Divaka PereraSchool of Cardiovascular Medicine and Sciences, St Thomas' Hospital Campus, King's College London, United Kingdom (D.P.).ORCID 0000-0001-6362-1291 Ethan KorngoldCardiovascular Center Aalst, AZORG, Aalst, Belgium (T.M., K.I., D.M., K.S., J.S., T. Storozhenko, F.B., E.W., A.W., B.D.B., C.C.).
Adriaan WilgenhofCardiovascular Center Aalst, AZORG, Aalst, Belgium (T.M., K.I., D.M., K.S., J.S., T. Storozhenko, F.B., E.W., A.W., B.D.B., C.C.).
Bernard De BruyneCardiovascular Center Aalst, AZORG, Aalst, Belgium (T.M., K.I., D.M., K.S., J.S., T. Storozhenko, F.B., E.W., A.W., B.D.B., C.C.).ORCID 0000-0001-6567-168X Nils P JohnsonWeatherhead PET Center, Division of Cardiology, Department of Medicine, McGovern Medical School at UTHealth and Memorial Hermann Hospital, Houston, TX (N.P.J.).ORCID 0000-0002-0897-2301 Carlos ColletCardiovascular Center Aalst, AZORG, Aalst, Belgium (T.M., K.I., D.M., K.S., J.S., T. Storozhenko, F.B., E.W., A.W., B.D.B., C.C.).ORCID 0000-0003-0227-0082 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
backgroundThe pullback pressure gradient (PPG) is a novel physiological metric that quantifies coronary artery disease patterns as focal or diffuse on a scale from 0 to 1. This study assessed the relationship between PPG and residual angina at 1 year.
methodsPPG Global is a prospective, investigator-initiated, single-arm, multicenter study that enrolled patients with at least 1 lesion with a fractional flow reserve ≤0.80 intended to be treated with percutaneous coronary intervention. After the PPG calculation, physicians could revise treatment assignment to medical therapy or coronary artery bypass graft surgery instead of percutaneous coronary intervention. Focal and diffuse disease were defined based on the median PPG value of 0.62. Patient-reported outcomes were assessed using the Seattle Angina Questionnaire at baseline and 1-year follow-up.
resultsThe study included 947 patients with PPG and the Seattle Angina Questionnaire at 1 year. The mean age was 67.6±10.2 years, 24% were female, and 29% had diabetes. At 1 year, patients with focal coronary artery disease reported less angina than those with diffuse disease (Seattle Angina Questionnaire angina frequency score, 95.3±9.9 versus 92.5±15.0;
conclusionsIn patients with flow-limiting coronary artery disease, a focal disease pattern defined by high PPG was associated with greater symptomatic relief at 1 year compared with diffuse disease (low PPG). By capturing the underlying pathophysiologic distribution of epicardial disease and its relation to post-treatment symptom relief, PPG may support a more tailored revascularization decision-making and percutaneous coronary intervention strategy.
Indexed as
Angina PectorisCardiac CatheterizationCoronary Artery DiseaseFractional Flow Reserve, MyocardialAgedCoronary Artery BypassFemaleHumansMaleMiddle AgedPatient Reported Outcome MeasuresPercutaneous Coronary InterventionPredictive Value of TestsProspective StudiesRecovery of FunctionTime Factorscoronary artery bypasscoronary artery diseasepatient-centered carepercutaneous coronary interventionphysicians
Identifiers
PMID41623057
PMCPMC12991326
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