ArticleJournal of endourology2026
Phenotyping of Idiopathic Calcium Oxalate Stone Formers Reveals Risk Factors for Papillary Lesions and Chronic Renal Function.
Article in Journal of endourology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Regulated Cell Death in Calcium Oxalate Stone Disease: From Tubular Epithelial Injury to Inflammatory Amplification.Journal of inflammation research · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundIdiopathic calcium oxalate stone formers (ICSFs) are a heterogeneous group. Randall's plaque (RP) and ductal plugs are two common papillary features observed in ICSFs. These papillary phenotypes, implicated in early stone formation, may be susceptible to different risk factors and have differing long-term health outcomes such as stone events and kidney function. We investigate these outcomes using clinical data from a well-characterized cohort of ICSFs undergoing endoscopic stone removal.
methodsICSFs undergoing stone removal procedures were consented for the study between August 2005 and May 2023. Papillae were imaged endoscopically per standard protocol. Two 24-hour urine tests were collected postoperatively while patients were off stone prevention medications. Chart review was performed for comorbidities, serum laboratories, and medication usage related to stone formation.
resultsWe identify three distinct phenotypes. Of 106 ICSFs, 37 had high plugging without plaque, 44 had high plaque without plugging, and 25 had low plaque and low plugging. High plugging ICSFs had lower estimated glomerular filtration rate (eGFR), increased history of prior urinary tract infection (UTI), and more prior stone events than ICSFs with high plaque or neither feature. Multivariable regression revealed plugging as a significant predictor of eGFR when correcting for age, gender, prior UTIs, and prior stone events.
conclusionsPlugging appears to be an important predictor for eGFR and multiple stone events. Prior UTIs appear to have a significant effect on plugging. RP did not appear to influence stone events or kidney function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.