Evidence map›Paper›PMID 41622794›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2026

Plasma Proteomic Profile of Chemotherapy-Induced Severe Neutropenia: A Pilot Discovery Phase Study.

Leticia Queiroz da Silva, Alexander Leonardo Silva-Junior, Licia C Silva-Costa, Ivanio Teixeira Borba-Junior, Bradley J Smith, Edilson Tadeu Andrade, Bruno Kosa Lino Duarte, Marcos Paulo Colella, Thiago Martins Santos, Daniel Martins-de-Souza and 1 more

Abstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Plasma Proteomic Profile of Chemotherapy-Induced Severe Neutropenia: A Pilot Discovery Phase Study.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Leticia Queiroz da SilvaSchool of Medical Sciences, University of Campinas, Campinas, SP, Brazil.ORCID https://orcid.org/0000-0003-1632-4678
Alexander Leonardo Silva-JuniorSchool of Medical Sciences, University of Campinas, Campinas, SP, Brazil.ORCID https://orcid.org/0000-0002-5645-252X
Licia C Silva-CostaInstitute of Biology, University of Campinas, Campinas, SP, Brazil.ORCID https://orcid.org/0000-0003-0292-4568
Ivanio Teixeira Borba-JuniorSchool of Medical Sciences, University of Campinas, Campinas, SP, Brazil.ORCID https://orcid.org/0000-0002-8241-165X
Bradley J SmithInstitute of Biology, University of Campinas, Campinas, SP, Brazil.ORCID https://orcid.org/0000-0003-1383-5851
Edilson Tadeu AndradeHematology and Hemotherapy Center, University of Campinas, Campinas, SP, Brazil.
Bruno Kosa Lino DuarteHematology and Hemotherapy Center, University of Campinas, Campinas, SP, Brazil.ORCID https://orcid.org/0000-0002-6155-3253
Marcos Paulo ColellaHematology and Hemotherapy Center, University of Campinas, Campinas, SP, Brazil.ORCID https://orcid.org/0000-0002-4292-6472
Thiago Martins SantosSchool of Medical Sciences, University of Campinas, Campinas, SP, Brazil.ORCID https://orcid.org/0000-0002-4686-3122
Daniel Martins-de-SouzaInstitute of Biology, University of Campinas, Campinas, SP, Brazil.ORCID https://orcid.org/0000-0003-3595-5846
Erich Vinicius De PaulaSchool of Medical Sciences, University of Campinas, Campinas, SP, Brazil.ORCID https://orcid.org/0000-0003-1539-7912

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) 2021/12945-6Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) 2022/13216-0Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) 2023/08178-5Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) 2025/04429-9
6 · The paper itself

Abstract

Transient severe neutropenia and thrombocytopenia are frequent during treatment of hematological malignancies and contribute to early mortality through sepsis and bleeding. While neutrophils and platelets are essential for host defense and tissue repair, little is known about immune adaptations during their depletion. In this pilot, discovery phase study, we evaluated the plasma proteome of 10 patients with chemotherapy-induced severe neutropenia and thrombocytopenia, prior to any clinical complication. At sampling, mean neutrophil and platelet counts were 0.15 ± 0.18 × 10

Indexed as

Antineoplastic AgentsNeutropeniaProteomeProteomicsAdultAgedFemaleHematologic NeoplasmsHumansMaleMiddle AgedPilot ProjectsThrombocytopeniaAntineoplastic AgentsProteomebiomarkersdrug therapyhematologic cancerimmunothrombosissepsissystem biology

Identifiers

PMID41622794
PMCPMC12862286

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.