Pretreatment C-Reactive Protein/Albumin Ratio Can Predict Severity of Radiotherapy-Induced Oral Mucositis in Advanced Laryngeal Cancer Patients.

Marcin Mazurek, Anna Brzozowska, Teresa Małecka-Massalska, Tomasz Powrózek

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Article in Oral diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 authors.

Marcin MazurekDepartment of Human Physiology of Chair of Preclinical Sciences, Medical University of Lublin, Lublin, Poland.

Anna BrzozowskaDepartment of Radiotherapy, St. John of Dukla Lublin Region Cancer Center, Lublin, Poland.

Teresa Małecka-MassalskaDepartment of Human Physiology of Chair of Preclinical Sciences, Medical University of Lublin, Lublin, Poland.

Tomasz PowrózekDepartment of Human Physiology of Chair of Preclinical Sciences, Medical University of Lublin, Lublin, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTreatment methods of laryngeal cancer (LC) often include radiotherapy (RT), commonly combined with cytotoxic drugs. This approach is associated with early adverse effects, notably oral mucositis (OM). The C-reactive protein to albumin ratio (CAR) is a promising novel biomarker used to assess the severity of inflammatory responses in various chronic conditions. The aim of this study was to evaluate the predictive value of pretreatment CAR for the occurrence and severity of OM of varying grades during RT in patients with LC.

methodsThe pretreatment CAR values were calculated in 68 patients treated with RT due to locally advanced or advanced LC.

resultsThe increased incidence of severe grade OM in LC patients between weeks III and VII of RT was significantly associated with higher CAR values. A high CAR was significantly correlated with an increased risk of grade 3 OM at the end of the III

conclusionsThe pretreatment CAR value indicates clinical utility in predicting the likelihood of severe OM induced by RT-based therapy in patients with LC.

Indexed as

C-Reactive ProteinLaryngeal NeoplasmsRadiation InjuriesSerum AlbuminStomatitisAdultAgedAged, 80 and overBiomarkersFemaleHumansMaleMiddle AgedPredictive Value of TestsSeverity of Illness IndexBiomarkersC-Reactive ProteinSerum AlbuminCARlaryngeal canceroral mucositisradiotherapy

Identifiers

PMID41622731

DOI10.1111/odi.70151

PMCPMC13457686

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