Evidence map›Paper›PMID 41622607›Full record

ArticleJournal of neurochemistry2026

Zinc-Mediated Lysosomal Destabilization Links Mitochondrial Damage to Neuronal Death in a Cellular MPP

Hyun-Seung Lee, Sun-Ah Kang, Jae-Won Eom, Min Seong Kim, Ji-Soo Kim, Yang-Hee Kim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hyun-Seung LeeDepartment of Integrative Bioscience and Biotechnology, Sejong University, Seoul, Republic of Korea.ORCID https://orcid.org/0000-0001-9546-5772
Sun-Ah KangDepartment of Integrative Bioscience and Biotechnology, Sejong University, Seoul, Republic of Korea.
Jae-Won EomDepartment of Integrative Bioscience and Biotechnology, Sejong University, Seoul, Republic of Korea.
Min Seong KimDepartment of Integrative Bioscience and Biotechnology, Sejong University, Seoul, Republic of Korea.
Ji-Soo KimDepartment of Integrative Bioscience and Biotechnology, Sejong University, Seoul, Republic of Korea.
Yang-Hee KimDepartment of Integrative Bioscience and Biotechnology, Sejong University, Seoul, Republic of Korea.

Funding

Korea Basic Science Institute 2023-NF001356National Research Foundation of Korea RS-2023-00242206National Research Foundation of Korea RS-2025-00560220Seoul RISE Center 2025-RISE-01-019-04
6 · The paper itself

Abstract

Dysregulation of autophagy and lysosomal function is central to Parkinson's disease (PD), yet the upstream mechanisms leading to lysosomal failure remain unclear. Across primary mouse cortical neurons, MT-3 deficient primary mouse astrocytes, human iPSC-derived midbrain dopaminergic neurons, and Rho

Indexed as

1-Methyl-4-phenylpyridiniumLysosomesMitochondriaNeuronsParkinson DiseaseZincAnimalsCell DeathCells, CulturedHumansMiceReactive Oxygen Species1-Methyl-4-phenylpyridiniumReactive Oxygen SpeciesZinclysosomal membrane permeabilization (LMP)mitochondriaParkinson's diseasereactive oxygen species (ROS)zinc

Identifiers

PMID41622607
PMCPMC12862199

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.