Evidence map›Paper›PMID 41622598›Full record

ArticleCNS neuroscience & therapeutics2026

Hydrogen-Mediated Activation of the Nrf2/HO-1 Signaling Pathway Improves Cognitive Impairment in Sleep-Deprived Mice.

QiFan Xiao, ShiRui Zhou, Bin Tang, YuQing Zhu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CNS neuroscience & therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

QiFan XiaoGeneral Practice, International Department of China-Japan Friendship Hospital, Beijing, China.
ShiRui ZhouGraduate School, Beijing University of Chinese Medicine, Beijing, China.
Bin TangGeneral Practice, International Department of China-Japan Friendship Hospital, Beijing, China.
YuQing ZhuGeneral Practice, International Department of China-Japan Friendship Hospital, Beijing, China.ORCID 0009-0006-0147-3645

Funding

National High Level Hospital Clinical Research Funding 2023-NHLHCRF-YYPPLC-ZR-23
6 · The paper itself

Abstract

aimsThis study investigated the effects of hydrogen (H

methodsA chronic sleep deprivation (SD) model was established using the modified multiple platform method, with 18 h of deprivation daily for 28 consecutive days. Cognitive function was evaluated using the Morris water maze and novel object recognition (NOR) test. Histopathological and biochemical analyses, including hematoxylin and eosin staining, Nissl staining, immunohistochemistry, and enzyme-linked immunosorbent assay, were performed to assess oxidative stress and inflammation-related markers.

resultsThe results demonstrated that H

conclusionThese results indicate that H

Indexed as

Cognitive DysfunctionHeme Oxygenase-1HydrogenMembrane ProteinsNF-E2-Related Factor 2Signal TransductionSleep DeprivationAnimalsMaleMaze LearningMiceOxidative StressHeme Oxygenase-1Hmox1 protein, mouseHydrogenMembrane ProteinsNfe2l2 protein, mouseNF-E2-Related Factor 2cognitive impairmenthydrogenneuroinflammationNrf2/HO‐1 signaling pathwayoxidative stresssleep deprivation

Identifiers

PMID41622598
PMCPMC12862102

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.