Evidence map›Paper›PMID 41622382›Full record

ArticleClinical oral investigations2026

Is single-shot antibiotic prophylaxis really enough for standard OMF-surgeries?

Lara Schorn, Daman Deep Singh, Felicitas Mrochen, Melanie Kempe, Felix Schrader, Majeed Rana, Christoph Sproll, Julian Lommen, Insa Joost

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical oral investigations, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Antimicrobial Stewardship in oral and maxillofacial surgery: melting the iceberg.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lara SchornDepartment of Oral-Maxillofacial and Facial Plastic Surgery, University Hospital Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Germany.
Daman Deep SinghDepartment of Oral-Maxillofacial and Facial Plastic Surgery, University Hospital Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Germany. DamanDeep.Singh@med.uni-duesseldorf.de.
Felicitas MrochenDepartment of Oral-Maxillofacial and Facial Plastic Surgery, University Hospital Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Germany.
Melanie KempeDepartment of Pharmacy, Helios Clinic Schwelm, Dr.-Moeller-Str. 15, 58332, Schwelm, Germany.
Felix SchraderDepartment of Oral-Maxillofacial and Facial Plastic Surgery, University Hospital Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Germany.
Majeed RanaDepartment of Oral-Maxillofacial and Facial Plastic Surgery, University Hospital Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Germany.
Christoph SprollDepartment of Oral-Maxillofacial and Facial Plastic Surgery, University Hospital Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Germany.
Julian LommenDepartment of Oral-Maxillofacial and Facial Plastic Surgery, University Hospital Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Germany.
Insa JoostInstitute of Medical Microbiology and Hospital Hygiene, Heinrich Heine University, Universitätsstr. 1, 40225, Duesseldorf, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesAntibiotic resistance and the development of multidrug-resistant pathogens are on the rise worldwide. This is mainly due to inappropriate or excessive use of antibiotics. There is a lack of evidence-based guidelines and studies for the administration of antibiotics in OMF surgery. In this study, a new shortened antibiotic prophylaxis regimen for six standard OMFS procedures (Fracture repair, plate removal, orthognathic surgery, TUROP, ND and bone augmentation) was introduced and evaluated for clinical outcomes and feasibility. MATERIALS AND

methods856 patients were enrolled in this study. They were monitored for postoperative complications such as dehiscence, fistula, signs of clinical infection, and laboratory markers of inflammation. Subgroup analyses were performed for clinically relevant procedure categories, including fractures, plate removal, and orthognathic surgery.

resultsAfter risk adjustment, reduced-duration antibiotic prophylaxis was not associated with adverse postoperative outcomes. Furthermore, a more restrictive administration as a single shot was associated with a shorter length of hospital stay (from 5.83 (± 7.92) to 4.32 (± 4.88) days (p = > 0.001)).

conclusionsA single dose of antibiotics was found to be sufficient for the oral and maxillofacial procedures evaluated. Implementation of a new policy of reduced antibiotic prophylaxis coincided with a shorter length of hospital stay. CLINICAL RELEVANCE: This study supports the growing body of evidence suggesting that shorter, procedure-tailored antibiotic regimens can be safe and effective, potentially reducing antimicrobial resistance and adverse drug effects without compromising surgical outcomes.

Indexed as

Anti-Bacterial AgentsAntibiotic ProphylaxisOral Surgical ProceduresPostoperative ComplicationsSurgical Wound InfectionAdultFemaleHumansLength of StayMaleMiddle AgedTreatment OutcomeAnti-Bacterial AgentsAntibiotic prophylaxisLength of hospital stayOMF surgeriesProlonged antibiotic prophylaxisSingle-shot antibiotic

Identifiers

PMID41622382
PMCPMC12861997

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.