Evidence map›Paper›PMID 41622361›Full record

ArticleApoptosis : an international journal on programmed cell death2026

CD95 ligand drives abdominal aortic aneurysm progression through Caspase-8-mediated GSDMD-dependent endothelial pyroptosis: modulation by SRC kinase.

Tian-Tian Ke, Chuan Yuan, Yong Yuan, Jin-Long Liu, Xue-Liang Zhou, Ji-Chun Liu, Wan-Fen Xiong, Zhi-Bo Liu

Abstract read
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In one paragraph

Article in Apoptosis : an international journal on programmed cell death, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tian-Tian KeDepartment of Anesthesiology and Operation, Medical Center of Anesthesiology and Pain, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, People's Republic of China.
Chuan YuanDepartment of Cardiovascular Surgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi, People's Republic of China.
Yong YuanDepartment of Cardiovascular Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, People's Republic of China.
Jin-Long LiuInstitute of Translational Medicine, Shanghai University, Shanghai, 200444, People's Republic of China.
Xue-Liang ZhouDepartment of Cardiovascular Surgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi, People's Republic of China.
Ji-Chun LiuDepartment of Cardiovascular Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, People's Republic of China.
Wan-Fen XiongDepartment of Surgery, University of Nebraska Medical Center, Omaha, NE, 68198-7690, USA. wxiong@unmc.edu.
Zhi-Bo LiuDepartment of Cardiovascular Surgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi, People's Republic of China. ndyfy05943@ncu.edu.cn.

Funding

Education Department of Jiangxi Province GJJ210151National Natural Science Foundation of China 82260102Natural Science Foundation of Jiangxi Province 20232BAB216013
6 · The paper itself

Abstract

Abdominal aortic aneurysm (AAA) progression is closely linked to inflammation and endothelial dysfunction. Our previous study has demonstrated that increased CD95 ligand (CD95L) and its downstream effector Caspase-8 in the aortic tissue, contributed to AAA by modulating inflammation. However, how the CD95L/Caspase-8 modulated aneurysmal inflammation remains poorly understood. This study investigates how CD95L/Caspase-8 signaling drives endothelial pyroptosis to exacerbate AAA. Using a CaCl

Indexed as

Aortic Aneurysm, AbdominalCaspase 8Endothelial CellsFas Ligand ProteinIntracellular Signaling Peptides and ProteinsPhosphate-Binding ProteinsPyroptosissrc-Family KinasesAnimalsApoptosis Regulatory ProteinsDisease Models, AnimalDisease ProgressionGasderminsHumansInflammasomesMaleApoptosis Regulatory ProteinsCasp8 protein, mouseCaspase 8Fas Ligand ProteinGasderminsGsdmd protein, mouseInflammasomesIntracellular Signaling Peptides and ProteinsNLR Family, Pyrin Domain-Containing 3 ProteinPhosphate-Binding Proteinssrc-Family KinasesAbdominal aortic aneurysmAortic endothelial cellsCaspase-8CD95LPyroptosis

Identifiers

PMID41622361

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.