Evidence map›Paper›PMID 41622190›Full record

SynthesisBMC oral health2026

Effects of mussel-inspired compounds on dentin bonding: a systematic review and meta-analysis.

Fangfei Peng, Yu Long, Huilin Gao, Shihan Huang, Yingxian Wei, Cheng Lu, Jinan He, Yuhong Ma, Yujun Lin, Likun Liang and 2 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Fangfei Peng *School of Dentistry, Shenzhen University Medical School, 1066 Xueyuan Avenue, Nanshan District, Shenzhen, 518055, China.
Yu Long *School of Dentistry, Shenzhen University Medical School, 1066 Xueyuan Avenue, Nanshan District, Shenzhen, 518055, China.
Huilin GaoGuangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction, Guangxi Clinical Research Center for Craniofacial Deformity, College & Hospital of Stomatology, Guangxi Medical University, No. 10 Shuangyong Road, Qingxiu District, Nanning, 530021, China.
Shihan HuangGuangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction, Guangxi Clinical Research Center for Craniofacial Deformity, College & Hospital of Stomatology, Guangxi Medical University, No. 10 Shuangyong Road, Qingxiu District, Nanning, 530021, China.
Yingxian WeiGuangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction, Guangxi Clinical Research Center for Craniofacial Deformity, College & Hospital of Stomatology, Guangxi Medical University, No. 10 Shuangyong Road, Qingxiu District, Nanning, 530021, China.
Cheng LuSchool of Dentistry, Shenzhen University Medical School, 1066 Xueyuan Avenue, Nanshan District, Shenzhen, 518055, China.
Jinan HeGuangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction, Guangxi Clinical Research Center for Craniofacial Deformity, College & Hospital of Stomatology, Guangxi Medical University, No. 10 Shuangyong Road, Qingxiu District, Nanning, 530021, China.
Yuhong MaGuangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction, Guangxi Clinical Research Center for Craniofacial Deformity, College & Hospital of Stomatology, Guangxi Medical University, No. 10 Shuangyong Road, Qingxiu District, Nanning, 530021, China.
Yujun LinGuangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction, Guangxi Clinical Research Center for Craniofacial Deformity, College & Hospital of Stomatology, Guangxi Medical University, No. 10 Shuangyong Road, Qingxiu District, Nanning, 530021, China.
Likun LiangGuangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction, Guangxi Clinical Research Center for Craniofacial Deformity, College & Hospital of Stomatology, Guangxi Medical University, No. 10 Shuangyong Road, Qingxiu District, Nanning, 530021, China.
Zhiyong ChenGuangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction, Guangxi Clinical Research Center for Craniofacial Deformity, College & Hospital of Stomatology, Guangxi Medical University, No. 10 Shuangyong Road, Qingxiu District, Nanning, 530021, China. chenzhiyong@sr.gxmu.edu.cn.
Kang LiSchool of Dentistry, Shenzhen University Medical School, 1066 Xueyuan Avenue, Nanshan District, Shenzhen, 518055, China. likang@szu.edu.cn.

Funding

Basic and Applied Basic Research Foundation of Guangdong Province 2023A1515110167Joint Project on Regional High-Incidence Diseases Research of Guangxi Natural Science Foundation 2024GXNSFAA010141National Clinical Key Specialty Construction Project CZ000037Stable Support Project of Shenzhen 20231120110249002
6 · The paper itself

Abstract

backgroundResin-based materials used in the treatment of dental caries face insufficient bonding durability at the dentin interface. Mussel-inspired compounds, as a novel class of bio-inspired materials, offer promising potential for enhancing dentin bonding performance. This meta-analysis assessed the efficacy of monomeric and polymeric mussel-inspired compounds on resin-dentin bond strength and/or anti-enzymatic effects.

methodsThis systematic review and meta-analysis was registered in PROSPERO (CRD42025649875). Following PRISMA guidelines, a systematic search covered PubMed, Web of Science, Cochrane Library, EMBASE, and Scopus up to March 1, 2025. Included studies compared experimental groups using mussel-inspired compounds to controls, assessing resin-dentin bond strength and/or anti-enzymatic effects. Risk of bias was assessed using the QUIN Tool. Statistical analysis involved standard pairwise meta-analysis and heterogeneity assessment. The publication bias was examined using funnel plots. A sensitivity analysis was conducted by excluding studies with positive controls.

resultsA total of 13 studies were included in systematic review and 12 studies in meta-analysis. The pooled results suggested that mussel-inspired compounds significantly enhanced the immediate bond strength (SMD = 0.91, p = 0.0008) and markedly reduced the bond strength degradation after aging (SMD = -3.97, p = 0.0001). Subgroup analysis showed the monomeric form significantly improved the immediate bond strength (SMD = 1.26, p < 0.00001) and reduced aging-related degradation (SMD = -4.00, p < 0.0001), while the polymeric form showed no significant effects. The mussel-inspired compounds also significantly suppressed collagen degradation, indicated by reduced hydroxyproline release (SMD = -9.04, p < 0.00001). Sensitivity analysis confirmed the robustness of these findings, as excluding studies with active positive controls yielded consistent and significant results.

conclusionsMonomeric mussel-inspired compounds enhance immediate dentin bond strength and improve its durability by mitigating aging-induced degradation and inhibiting collagen degradation, while polymeric compounds demonstrate no statistically significant benefits.

Indexed as

BivalviaDental BondingDentin-Bonding AgentsAnimalsHumansDentin-Bonding AgentsBond strengthDentin bondingDentin collagenMussel-inspired compounds

Identifiers

PMID41622190
PMCPMC12952142

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.