Evidence map›Paper›PMID 41622147›Full record

ArticleMolecular pain

Circulating cellular senescence biomarkers in persons with chronic knee osteoarthritis pain: An exploratory study.

Muhammad Abbas, Javier A Tamargo, Carlos J Cruz, Yutao Zhang, Stephanie Wohlgemuth, Kevin Wu, Li Chen, Roland Staud, Roger B Fillingim, Christiaan Leeuwenburgh and 1 more

Abstract read
In one paragraph

Article in Molecular pain. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Muhammad AbbasDepartment of Community Dentistry and Behavioral Science, University of Florida, Gainesville, FL, USA.ORCID 0000-0002-4453-0981
Javier A TamargoDepartment of Community Dentistry and Behavioral Science, University of Florida, Gainesville, FL, USA.ORCID 0000-0001-9385-9049
Carlos J CruzDepartment of Community Dentistry and Behavioral Science, University of Florida, Gainesville, FL, USA.ORCID 0000-0002-7424-9867
Yutao ZhangDepartment of Biostatistics, University of Florida, Gainesville, FL, USA.
Stephanie WohlgemuthDepartment of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL, USA.
Kevin WuDepartment of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL, USA.
Li ChenDepartment of Biostatistics, University of Florida, Gainesville, FL, USA.
Roland StaudDepartment of Medicine, College of Medicine, University of Florida, Gainesville, FL, USA.
Roger B FillingimDepartment of Community Dentistry and Behavioral Science, University of Florida, Gainesville, FL, USA.
Christiaan LeeuwenburghDepartment of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL, USA.ORCID 0000-0003-0826-4257
Yenisel Cruz-AlmeidaDepartment of Community Dentistry and Behavioral Science, University of Florida, Gainesville, FL, USA.ORCID 0000-0002-0065-0236

Funding

the Integrative and Multidisciplinary Pain and Aging Research Training (IMPART) ProgramT32AG049673 · NIA · UNIVERSITY OF FLORIDA · PI FILLINGIM, ROGER B · 2015 to 2024
$3.2M
Computational modeling of genetic variations by multi-omics integration todecipher personal genomeR35GM142701 · NIGMS · UNIVERSITY OF FLORIDA · PI CHEN, LI · 2021 to 2025
$1.8M
University of Florida Partnerships Across Interdisciplinary Networks: Training through Engineering, epidemiology & Addiction Medicine (UF PAIN TEAM)T90AR085527 · NIAMS · UNIVERSITY OF FLORIDA · PI Kyle D Allen, Yenisel Cruz-Almeida · 2024 to 2026
$1.0M
University of Florida Partnerships Across Interdisciplinary Networks: Training through Engineering, epidemiology & Addiction Medicine (UF PAIN TEAM)R90AR085802 · NIAMS · UNIVERSITY OF FLORIDA · PI Kyle D Allen, Yenisel Cruz-Almeida · 2024 to 2026
$1.0M
NIAMS NIH HHS R90 AR085802NIAMS NIH HHS T90 AR085527NIA NIH HHS L32 AG096730NIA NIH HHS T32 AG049673NIGMS NIH HHS R35 GM142701
6 · The paper itself

Abstract

The senescence-associated secretory phenotype (SASP) contributes to tissue degeneration and inflammation, yet its role in osteoarthritis (OA)-related pain remains poorly understood. We hypothesized that circulating SASP markers would be associated with distinct OA-pain phenotypes, defined by pain impact and radiographic OA (ROA) severity. A subset of middle-to-older-aged adults (45-85 years) from a larger multi-site study (

Indexed as

BiomarkersCellular SenescenceChronic PainOsteoarthritis, KneeAgedAged, 80 and overFemaleHumansMaleMiddle AgedBiomarkersbiological agingCellular senescencechronic painosteoarthritisSASP factors

Identifiers

PMID41622147
PMCPMC12929831

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.