Evidence map›Paper›PMID 41621945›Full record

ArticleThe Journal of rheumatology2026

Genome-Wide Association Study Identifies Genetic Loci for Antibody Response to SARS-CoV-2 Vaccines in Patients With Systemic Autoimmune Diseases and Healthy Individuals.

Kwangwoo Kim, Dillon Claybaugh, Eduardo Patino-Martinez, Yenealem Temesgen-Oyelakin, Elaine Poncio, Jun Chu, Michael Davis, Alice Fike, Yanira Ruiz-Perdomo, Julie Onyechi and 27 more

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Article in The Journal of rheumatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

37 authors.

Kwangwoo KimK. Kim, PhD, Department of Biology, Kyung Hee University, Seoul, Republic of Korea, Department of Biomedical and Pharmaceutical Sciences, Kyung Hee University, Seoul, Republic of Korea, and National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland, USA.
Dillon ClaybaughD. Claybaugh, BS, E. Patino-Martinez, PhD, Y. Temesgen-Oyelakin, RN, E. Poncio, RN, J. Chu, MSN, CRNP, M. Davis, MSN, CRNP, A. Fike, CRNP, Y. Ruiz-Perdomo, FNP-BC, MSN, J. Onyechi, PA-C, N. Spencer, RN, MSCN, CCRP, L.B. Lewandowski, MD, MS, L.M. Franco, MD, Z. Manna, MSc, S. Gupta, MD, K.A. Quinn, MD, P.C. Grayson, MD, MSc, I. Pinal-Fernandez, MD, PhD, PhD, A.L. Mammen, MD, PhD, S. Hasni, MD, M.J. Kaplan, MD, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland, USA.
Eduardo Patino-MartinezD. Claybaugh, BS, E. Patino-Martinez, PhD, Y. Temesgen-Oyelakin, RN, E. Poncio, RN, J. Chu, MSN, CRNP, M. Davis, MSN, CRNP, A. Fike, CRNP, Y. Ruiz-Perdomo, FNP-BC, MSN, J. Onyechi, PA-C, N. Spencer, RN, MSCN, CCRP, L.B. Lewandowski, MD, MS, L.M. Franco, MD, Z. Manna, MSc, S. Gupta, MD, K.A. Quinn, MD, P.C. Grayson, MD, MSc, I. Pinal-Fernandez, MD, PhD, PhD, A.L. Mammen, MD, PhD, S. Hasni, MD, M.J. Kaplan, MD, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland, USA.
Yenealem Temesgen-OyelakinD. Claybaugh, BS, E. Patino-Martinez, PhD, Y. Temesgen-Oyelakin, RN, E. Poncio, RN, J. Chu, MSN, CRNP, M. Davis, MSN, CRNP, A. Fike, CRNP, Y. Ruiz-Perdomo, FNP-BC, MSN, J. Onyechi, PA-C, N. Spencer, RN, MSCN, CCRP, L.B. Lewandowski, MD, MS, L.M. Franco, MD, Z. Manna, MSc, S. Gupta, MD, K.A. Quinn, MD, P.C. Grayson, MD, MSc, I. Pinal-Fernandez, MD, PhD, PhD, A.L. Mammen, MD, PhD, S. Hasni, MD, M.J. Kaplan, MD, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland, USA.
Elaine PoncioD. Claybaugh, BS, E. Patino-Martinez, PhD, Y. Temesgen-Oyelakin, RN, E. Poncio, RN, J. Chu, MSN, CRNP, M. Davis, MSN, CRNP, A. Fike, CRNP, Y. Ruiz-Perdomo, FNP-BC, MSN, J. Onyechi, PA-C, N. Spencer, RN, MSCN, CCRP, L.B. Lewandowski, MD, MS, L.M. Franco, MD, Z. Manna, MSc, S. Gupta, MD, K.A. Quinn, MD, P.C. Grayson, MD, MSc, I. Pinal-Fernandez, MD, PhD, PhD, A.L. Mammen, MD, PhD, S. Hasni, MD, M.J. Kaplan, MD, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland, USA.
Jun ChuD. Claybaugh, BS, E. Patino-Martinez, PhD, Y. Temesgen-Oyelakin, RN, E. Poncio, RN, J. Chu, MSN, CRNP, M. Davis, MSN, CRNP, A. Fike, CRNP, Y. Ruiz-Perdomo, FNP-BC, MSN, J. Onyechi, PA-C, N. Spencer, RN, MSCN, CCRP, L.B. Lewandowski, MD, MS, L.M. Franco, MD, Z. Manna, MSc, S. Gupta, MD, K.A. Quinn, MD, P.C. Grayson, MD, MSc, I. Pinal-Fernandez, MD, PhD, PhD, A.L. Mammen, MD, PhD, S. Hasni, MD, M.J. Kaplan, MD, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland, USA.
Michael DavisD. Claybaugh, BS, E. Patino-Martinez, PhD, Y. Temesgen-Oyelakin, RN, E. Poncio, RN, J. Chu, MSN, CRNP, M. Davis, MSN, CRNP, A. Fike, CRNP, Y. Ruiz-Perdomo, FNP-BC, MSN, J. Onyechi, PA-C, N. Spencer, RN, MSCN, CCRP, L.B. Lewandowski, MD, MS, L.M. Franco, MD, Z. Manna, MSc, S. Gupta, MD, K.A. Quinn, MD, P.C. Grayson, MD, MSc, I. Pinal-Fernandez, MD, PhD, PhD, A.L. Mammen, MD, PhD, S. Hasni, MD, M.J. Kaplan, MD, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland, USA.
Alice FikeD. Claybaugh, BS, E. Patino-Martinez, PhD, Y. Temesgen-Oyelakin, RN, E. Poncio, RN, J. Chu, MSN, CRNP, M. Davis, MSN, CRNP, A. Fike, CRNP, Y. Ruiz-Perdomo, FNP-BC, MSN, J. Onyechi, PA-C, N. Spencer, RN, MSCN, CCRP, L.B. Lewandowski, MD, MS, L.M. Franco, MD, Z. Manna, MSc, S. Gupta, MD, K.A. Quinn, MD, P.C. Grayson, MD, MSc, I. Pinal-Fernandez, MD, PhD, PhD, A.L. Mammen, MD, PhD, S. Hasni, MD, M.J. Kaplan, MD, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland, USA.
Yanira Ruiz-PerdomoD. Claybaugh, BS, E. Patino-Martinez, PhD, Y. Temesgen-Oyelakin, RN, E. Poncio, RN, J. Chu, MSN, CRNP, M. Davis, MSN, CRNP, A. Fike, CRNP, Y. Ruiz-Perdomo, FNP-BC, MSN, J. Onyechi, PA-C, N. Spencer, RN, MSCN, CCRP, L.B. Lewandowski, MD, MS, L.M. Franco, MD, Z. Manna, MSc, S. Gupta, MD, K.A. Quinn, MD, P.C. Grayson, MD, MSc, I. Pinal-Fernandez, MD, PhD, PhD, A.L. Mammen, MD, PhD, S. Hasni, MD, M.J. Kaplan, MD, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland, USA.
Julie OnyechiD. Claybaugh, BS, E. Patino-Martinez, PhD, Y. Temesgen-Oyelakin, RN, E. Poncio, RN, J. Chu, MSN, CRNP, M. Davis, MSN, CRNP, A. Fike, CRNP, Y. Ruiz-Perdomo, FNP-BC, MSN, J. Onyechi, PA-C, N. Spencer, RN, MSCN, CCRP, L.B. Lewandowski, MD, MS, L.M. Franco, MD, Z. Manna, MSc, S. Gupta, MD, K.A. Quinn, MD, P.C. Grayson, MD, MSc, I. Pinal-Fernandez, MD, PhD, PhD, A.L. Mammen, MD, PhD, S. Hasni, MD, M.J. Kaplan, MD, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland, USA.
Margaret BeachM. Beach, PA, E. Pelayo, RN, B. Warner, DDS, PhD, MPH, National Institute of Dental and Craniofacial Research, Bethesda, Maryland, USA.
Lilian HowardL. Howard, CRNP, M.A. Waldman, MD, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA.
Eileen PelayoM. Beach, PA, E. Pelayo, RN, B. Warner, DDS, PhD, MPH, National Institute of Dental and Craniofacial Research, Bethesda, Maryland, USA.
Nancy SpencerD. Claybaugh, BS, E. Patino-Martinez, PhD, Y. Temesgen-Oyelakin, RN, E. Poncio, RN, J. Chu, MSN, CRNP, M. Davis, MSN, CRNP, A. Fike, CRNP, Y. Ruiz-Perdomo, FNP-BC, MSN, J. Onyechi, PA-C, N. Spencer, RN, MSCN, CCRP, L.B. Lewandowski, MD, MS, L.M. Franco, MD, Z. Manna, MSc, S. Gupta, MD, K.A. Quinn, MD, P.C. Grayson, MD, MSc, I. Pinal-Fernandez, MD, PhD, PhD, A.L. Mammen, MD, PhD, S. Hasni, MD, M.J. Kaplan, MD, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland, USA.
Martha SullyM. Sully, BSN, RN, Office of Research Support and Compliance, National Institutes of Health Clinical Center, Bethesda, Maryland, USA.
Rita VolochayevR. Volochayev, PhD, CRNP, CPMN, A. Schiffenbauer, MD, L.G. Rider, MD, National Institute of Environmental Health Sciences, Bethesda, Maryland, USA.
Sophie KellyS. Kelly, BA, S. Porche, BS, H.R. Kalish, PhD, National Institute of Biomedical Imaging and Bioengineering, Bethesda, Maryland, USA.
Sarah PorcheS. Kelly, BA, S. Porche, BS, H.R. Kalish, PhD, National Institute of Biomedical Imaging and Bioengineering, Bethesda, Maryland, USA.
Laura B LewandowskiD. Claybaugh, BS, E. Patino-Martinez, PhD, Y. Temesgen-Oyelakin, RN, E. Poncio, RN, J. Chu, MSN, CRNP, M. Davis, MSN, CRNP, A. Fike, CRNP, Y. Ruiz-Perdomo, FNP-BC, MSN, J. Onyechi, PA-C, N. Spencer, RN, MSCN, CCRP, L.B. Lewandowski, MD, MS, L.M. Franco, MD, Z. Manna, MSc, S. Gupta, MD, K.A. Quinn, MD, P.C. Grayson, MD, MSc, I. Pinal-Fernandez, MD, PhD, PhD, A.L. Mammen, MD, PhD, S. Hasni, MD, M.J. Kaplan, MD, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland, USA.
Luis M FrancoD. Claybaugh, BS, E. Patino-Martinez, PhD, Y. Temesgen-Oyelakin, RN, E. Poncio, RN, J. Chu, MSN, CRNP, M. Davis, MSN, CRNP, A. Fike, CRNP, Y. Ruiz-Perdomo, FNP-BC, MSN, J. Onyechi, PA-C, N. Spencer, RN, MSCN, CCRP, L.B. Lewandowski, MD, MS, L.M. Franco, MD, Z. Manna, MSc, S. Gupta, MD, K.A. Quinn, MD, P.C. Grayson, MD, MSc, I. Pinal-Fernandez, MD, PhD, PhD, A.L. Mammen, MD, PhD, S. Hasni, MD, M.J. Kaplan, MD, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland, USA.
Zerai MannaD. Claybaugh, BS, E. Patino-Martinez, PhD, Y. Temesgen-Oyelakin, RN, E. Poncio, RN, J. Chu, MSN, CRNP, M. Davis, MSN, CRNP, A. Fike, CRNP, Y. Ruiz-Perdomo, FNP-BC, MSN, J. Onyechi, PA-C, N. Spencer, RN, MSCN, CCRP, L.B. Lewandowski, MD, MS, L.M. Franco, MD, Z. Manna, MSc, S. Gupta, MD, K.A. Quinn, MD, P.C. Grayson, MD, MSc, I. Pinal-Fernandez, MD, PhD, PhD, A.L. Mammen, MD, PhD, S. Hasni, MD, M.J. Kaplan, MD, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland, USA.
Sarthak GuptaD. Claybaugh, BS, E. Patino-Martinez, PhD, Y. Temesgen-Oyelakin, RN, E. Poncio, RN, J. Chu, MSN, CRNP, M. Davis, MSN, CRNP, A. Fike, CRNP, Y. Ruiz-Perdomo, FNP-BC, MSN, J. Onyechi, PA-C, N. Spencer, RN, MSCN, CCRP, L.B. Lewandowski, MD, MS, L.M. Franco, MD, Z. Manna, MSc, S. Gupta, MD, K.A. Quinn, MD, P.C. Grayson, MD, MSc, I. Pinal-Fernandez, MD, PhD, PhD, A.L. Mammen, MD, PhD, S. Hasni, MD, M.J. Kaplan, MD, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland, USA.
Amy HutchinsonA. Hutchinson, MS, Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Rockville, Maryland, USA.
Lisa MirabelloL. Mirabello, PhD, V. Vij, MPH, MS, S.J. Chanock, MD, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Vibha VijL. Mirabello, PhD, V. Vij, MPH, MS, S.J. Chanock, MD, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Kaitlin A QuinnD. Claybaugh, BS, E. Patino-Martinez, PhD, Y. Temesgen-Oyelakin, RN, E. Poncio, RN, J. Chu, MSN, CRNP, M. Davis, MSN, CRNP, A. Fike, CRNP, Y. Ruiz-Perdomo, FNP-BC, MSN, J. Onyechi, PA-C, N. Spencer, RN, MSCN, CCRP, L.B. Lewandowski, MD, MS, L.M. Franco, MD, Z. Manna, MSc, S. Gupta, MD, K.A. Quinn, MD, P.C. Grayson, MD, MSc, I. Pinal-Fernandez, MD, PhD, PhD, A.L. Mammen, MD, PhD, S. Hasni, MD, M.J. Kaplan, MD, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland, USA.
Peter C GraysonD. Claybaugh, BS, E. Patino-Martinez, PhD, Y. Temesgen-Oyelakin, RN, E. Poncio, RN, J. Chu, MSN, CRNP, M. Davis, MSN, CRNP, A. Fike, CRNP, Y. Ruiz-Perdomo, FNP-BC, MSN, J. Onyechi, PA-C, N. Spencer, RN, MSCN, CCRP, L.B. Lewandowski, MD, MS, L.M. Franco, MD, Z. Manna, MSc, S. Gupta, MD, K.A. Quinn, MD, P.C. Grayson, MD, MSc, I. Pinal-Fernandez, MD, PhD, PhD, A.L. Mammen, MD, PhD, S. Hasni, MD, M.J. Kaplan, MD, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland, USA.
Adam SchiffenbauerR. Volochayev, PhD, CRNP, CPMN, A. Schiffenbauer, MD, L.G. Rider, MD, National Institute of Environmental Health Sciences, Bethesda, Maryland, USA.
Lisa G RiderR. Volochayev, PhD, CRNP, CPMN, A. Schiffenbauer, MD, L.G. Rider, MD, National Institute of Environmental Health Sciences, Bethesda, Maryland, USA.
Iago Pinal-FernandezD. Claybaugh, BS, E. Patino-Martinez, PhD, Y. Temesgen-Oyelakin, RN, E. Poncio, RN, J. Chu, MSN, CRNP, M. Davis, MSN, CRNP, A. Fike, CRNP, Y. Ruiz-Perdomo, FNP-BC, MSN, J. Onyechi, PA-C, N. Spencer, RN, MSCN, CCRP, L.B. Lewandowski, MD, MS, L.M. Franco, MD, Z. Manna, MSc, S. Gupta, MD, K.A. Quinn, MD, P.C. Grayson, MD, MSc, I. Pinal-Fernandez, MD, PhD, PhD, A.L. Mammen, MD, PhD, S. Hasni, MD, M.J. Kaplan, MD, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland, USA.
Andrew L MammenD. Claybaugh, BS, E. Patino-Martinez, PhD, Y. Temesgen-Oyelakin, RN, E. Poncio, RN, J. Chu, MSN, CRNP, M. Davis, MSN, CRNP, A. Fike, CRNP, Y. Ruiz-Perdomo, FNP-BC, MSN, J. Onyechi, PA-C, N. Spencer, RN, MSCN, CCRP, L.B. Lewandowski, MD, MS, L.M. Franco, MD, Z. Manna, MSc, S. Gupta, MD, K.A. Quinn, MD, P.C. Grayson, MD, MSc, I. Pinal-Fernandez, MD, PhD, PhD, A.L. Mammen, MD, PhD, S. Hasni, MD, M.J. Kaplan, MD, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland, USA.
Heather R KalishS. Kelly, BA, S. Porche, BS, H.R. Kalish, PhD, National Institute of Biomedical Imaging and Bioengineering, Bethesda, Maryland, USA.
Meryl A WaldmanL. Howard, CRNP, M.A. Waldman, MD, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA.
Blake WarnerM. Beach, PA, E. Pelayo, RN, B. Warner, DDS, PhD, MPH, National Institute of Dental and Craniofacial Research, Bethesda, Maryland, USA.
Sarfaraz HasniD. Claybaugh, BS, E. Patino-Martinez, PhD, Y. Temesgen-Oyelakin, RN, E. Poncio, RN, J. Chu, MSN, CRNP, M. Davis, MSN, CRNP, A. Fike, CRNP, Y. Ruiz-Perdomo, FNP-BC, MSN, J. Onyechi, PA-C, N. Spencer, RN, MSCN, CCRP, L.B. Lewandowski, MD, MS, L.M. Franco, MD, Z. Manna, MSc, S. Gupta, MD, K.A. Quinn, MD, P.C. Grayson, MD, MSc, I. Pinal-Fernandez, MD, PhD, PhD, A.L. Mammen, MD, PhD, S. Hasni, MD, M.J. Kaplan, MD, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland, USA.
Stephen J ChanockL. Mirabello, PhD, V. Vij, MPH, MS, S.J. Chanock, MD, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Mariana J KaplanD. Claybaugh, BS, E. Patino-Martinez, PhD, Y. Temesgen-Oyelakin, RN, E. Poncio, RN, J. Chu, MSN, CRNP, M. Davis, MSN, CRNP, A. Fike, CRNP, Y. Ruiz-Perdomo, FNP-BC, MSN, J. Onyechi, PA-C, N. Spencer, RN, MSCN, CCRP, L.B. Lewandowski, MD, MS, L.M. Franco, MD, Z. Manna, MSc, S. Gupta, MD, K.A. Quinn, MD, P.C. Grayson, MD, MSc, I. Pinal-Fernandez, MD, PhD, PhD, A.L. Mammen, MD, PhD, S. Hasni, MD, M.J. Kaplan, MD, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland, USA; mariana.kaplan@nih.gov.

Funding

WORK ORDER 126643 B539 EXPAND IC SUITE75N91019D00024 · NIAID · LEIDOS BIOMEDICAL RESEARCH, INC. · PI BRISCOE, LYNN · 2019 to 2025
$3932.6M
Systemic AutoimmunityZIAAR041199 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI KAPLAN, MARIANA · 2014 to 2025
$32.5M
Modulation of chronic inflammatory responses by COVID19ZIAAR041212 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI KAPLAN, MARIANA · 2021 to 2025
$1.2M
Intramural NIH HHS ZIA AR041199Intramural NIH HHS ZIA AR041212NCI NIH HHS 75N91019D00024Wellcome Trust
6 · The paper itself

Abstract

objectiveThe efficacy of nucleic acid-based vaccines against SARS-CoV-2 varies across individuals, partly due to genetic factors influencing neutralizing antibody production. In patients with systemic autoimmune diseases (SADs), this response may be further altered by immune dysregulation.

methodsWe conducted a genome-wide association study (GWAS) to identify genetic variants associated with postvaccination anti-SARS-CoV-2 IgG antibody levels and to assess whether these associations differ between patients with SAD and healthy individuals.

resultsThe study included 165 participants (138 with SADs, 27 healthy controls), all of whom received nucleic acid-based vaccines. Antibody levels targeting the spike protein receptor-binding domain (RBD) and nucleocapsid were measured between 1 and 12 months after vaccination. GWAS results were metaanalyzed with data from a previously published GWAS with 1076 healthy individuals. We identified a novel association near

conclusionThis study highlights both MHC and non-MHC genetic contributions to SARS-CoV-2 vaccine responses and suggests these effects are consistent across patients with SADs and healthy individuals, supporting standard vaccination strategies for individuals with systemic autoimmune conditions.

Indexed as

Antibodies, ViralAntibody FormationAutoimmune DiseasesCOVID-19COVID-19 VaccinesSARS-CoV-2AdultAgedFemaleGenetic LociGenome-Wide Association StudyHumansImmunoglobulin GMaleMiddle AgedPolymorphism, Single NucleotideAntibodies, ViralCOVID-19 VaccinesImmunoglobulin Gautoimmunitygenetic studiesvaccines

Identifiers

PMID41621945
PMCPMC12866942

What OpenQuestion holds

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Read underepoch 390

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.