Evidence map›Paper›PMID 41621884›Full record

ArticleInternal medicine (Tokyo, Japan)2026

Warm Autoimmune Hemolytic Anemia Associated with Pancreatic Adenocarcinoma Showing Ectopic Expression of Band 3 Protein: A Case Report.

Akari Goto, Makoto Yoshida, Ryosei Murai, Hiroto Horiguchi, Satoshi Iyama, Kazuma Ishikawa, Satoshi Takahashi, Kohichi Takada, Masayoshi Kobune

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Akari GotoDepartment of Internal Medicine, Division of Hematology, Sapporo Medical University School of Medicine, Japan.
Makoto YoshidaDepartment of Internal Medicine, Division of Medical Oncology, Sapporo Medical University School of Medicine, Japan.
Ryosei MuraiDepartment of Clinical Laboratory Medicine, Sapporo Medical University School of Medicine, Japan.
Hiroto HoriguchiDepartment of Internal Medicine, Division of Hematology, Sapporo Medical University School of Medicine, Japan.
Satoshi IyamaDepartment of Internal Medicine, Division of Hematology, Sapporo Medical University School of Medicine, Japan.
Kazuma IshikawaDepartment of Internal Medicine, Division of Medical Oncology, Sapporo Medical University School of Medicine, Japan.
Satoshi TakahashiDepartment of Internal Medicine, Division of Medical Oncology, Sapporo Medical University School of Medicine, Japan.
Kohichi TakadaDepartment of Internal Medicine, Division of Medical Oncology, Sapporo Medical University School of Medicine, Japan.
Masayoshi KobuneDepartment of Internal Medicine, Division of Hematology, Sapporo Medical University School of Medicine, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autoimmune hemolytic anemia (AIHA) is rare in solid tumors and may represent a paraneoplastic phenomenon. We describe the case of a 73-year-old woman with unresectable pancreatic adenocarcinoma who developed steroid-refractory warm AIHA. Prednisolone partially improved her anemia but not her hemolysis. Chemotherapy with modified FOLFIRINOX followed by gemcitabine plus nab-paclitaxel improved both the tumor and anemia, enabling steroid tapering. Conversion surgery revealed the ectopic expression of band 3 in tumor cells. This case suggests that anti-band 3 antibodies may mediate paraneoplastic AIHA and emphasizes the importance of tumor control in steroid-refractory cases.

Indexed as

AdenocarcinomaAnemia, Hemolytic, AutoimmuneAnion Exchange Protein 1, ErythrocytePancreatic NeoplasmsAgedAlbuminsAntineoplastic Combined Chemotherapy ProtocolsDeoxycytidineFemaleFluorouracilGemcitabineHumansIrinotecanLeucovorinOxaliplatinPaclitaxel130-nm albumin-bound paclitaxelAlbuminsAnion Exchange Protein 1, ErythrocyteDeoxycytidineFluorouracilfolfirinoxGemcitabineIrinotecanLeucovorinOxaliplatinPaclitaxelPrednisoloneband 3 proteinectopic expressionpancreatic adenocarcinomaparaneoplastic syndromesteroid-refractory anemiawarm autoimmune hemolytic anemia

Identifiers

PMID41621884
PMCPMC13668775

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.