Evidence map›Paper›PMID 41621873›Full record

ReviewInternal medicine (Tokyo, Japan)2026

Anti-citrullinated Protein Antibody-positive Arthralgia Associated with an L110P-E148Q Double Heterozygote: A Case-based Review.

Kazuhiro Itoh, Hiroshi Tsutani, Nozomi Otsuki, Atsushi Kuwata, Chiyo Kiriba, Yoshimasa Urasaki, Masamichi Ikawa, Hiromichi Iwasaki, Yasuhiko Mitsuke

Abstract readCase ReportsReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Internal medicine (Tokyo, Japan), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kazuhiro ItohDepartment of Internal Medicine, NHO Awara National Hospital, Japan.
Hiroshi TsutaniDepartment of Internal Medicine, NHO Awara National Hospital, Japan.
Nozomi OtsukiDepartment of Internal Medicine, NHO Awara National Hospital, Japan.
Atsushi KuwataDepartment of Internal Medicine, NHO Awara National Hospital, Japan.
Chiyo KiribaDepartment of Internal Medicine, NHO Awara National Hospital, Japan.
Yoshimasa UrasakiDepartment of Internal Medicine, NHO Awara National Hospital, Japan.
Masamichi IkawaDepartment of Community Health Science, Faculty of Medical Sciences, University of Fukui, Japan.
Hiromichi IwasakiDepartment of Community Health Science, Faculty of Medical Sciences, University of Fukui, Japan.
Yasuhiko MitsukeDepartment of Internal Medicine, NHO Awara National Hospital, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 42-year-old woman with positive anti-citrullinated protein antibody (ACPA) and rheumatoid factor (RF) levels exhibited arthralgia, but she did not fulfill the criteria for rheumatoid arthritis (RA). Subsequently, the patient exhibited episodic monoarthritis with a remarkable response to colchicine. An analysis of the MEFV gene identified heterozygous variants, L110P and E148Q, thus indicating a colchicine-responsive autoinflammatory condition. The patient was later diagnosed with RA and achieved remission with abatacept and colchicine. This case illustrates that ACPA-positive arthralgia evolves into RA through an autoinflammatory mechanism, thereby underscoring the diagnostic difficulties arising from the convergence of both autoimmune and autoinflammatory characteristics.

Indexed as

Anti-Citrullinated Protein AntibodiesArthralgiaArthritis, RheumatoidPyrinAdultColchicineFemaleHeterozygoteHumansMutationAnti-Citrullinated Protein AntibodiesColchicineMEFV protein, humanPyrinanti-cyclic citrullinated peptide antibodiesarthralgiafamilial Mediterranean feverMEFV gene variantsrheumatoid factor

Identifiers

PMID41621873
PMCPMC13627500

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.