Evidence map›Paper›PMID 41621870›Full record

ArticleInternal medicine (Tokyo, Japan)2026

Fungal Sensitization and the Manifestation of Asthmatic Features in Chronic Obstructive Pulmonary Disease.

Yuta Kono, Naoya Aoshiba, Reimi Mizushima, Mariko Kogami, Mayuko Ishiwari, Ryota Kikuchi, Kenichi Kobayashi, Yuki Togashi, Shinji Abe

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In one paragraph

Article in Internal medicine (Tokyo, Japan), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Yuta KonoDepartment of Respiratory Medicine, Tokyo Medical University, Japan.
Naoya AoshibaDepartment of Respiratory Medicine, Tokyo Medical University, Japan.
Reimi MizushimaDepartment of Respiratory Medicine, Tokyo Medical University, Japan.
Mariko KogamiDepartment of Respiratory Medicine, Tokyo Medical University, Japan.
Mayuko IshiwariDepartment of Respiratory Medicine, Tokyo Medical University, Japan.
Ryota KikuchiDepartment of Respiratory Medicine, Tokyo Medical University, Japan.
Kenichi KobayashiDepartment of Respiratory Medicine, Tokyo Medical University, Japan.
Yuki TogashiDepartment of Respiratory Medicine, Tokyo Medical University, Japan.
Shinji AbeDepartment of Respiratory Medicine, Tokyo Medical University, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective Fungal sensitization is known to be prevalent in chronic obstructive pulmonary disease (COPD) and it is recognized as a risk factor for severe asthma. However, its relationship to the development of asthmatic features in COPD remains unclear. Because the diagnostic criteria for asthma-COPD overlap (ACO) are not standardized, we focused on the specific asthmatic features that form the diagnostic basis of ACO, namely, blood eosinophilia and recurrent wheezing, to clarify how fungal sensitization contributes to their manifestation in COPD. Methods We retrospectively analyzed data from 72 patients with COPD who had specific immunoglobulin E (IgE) levels measured at the Tokyo Medical University Hospital between October 2019 and January 2024. The associations between fungal sensitization and clinical features, including the blood eosinophil count and recurrent wheezing, were analyzed. Results Fungal sensitization was observed in 38% of patients. Patients with fungal sensitization had significantly higher blood eosinophil counts than those without fungal sensitization, whereas no significant differences were found for other aeroallergens. Moreover, fungal sensitization was independently associated with both an elevated blood eosinophil count [≥300 cells/mm

Indexed as

AsthmaAsthma-Chronic Obstructive Pulmonary Disease Overlap SyndromeFungiPulmonary Disease, Chronic ObstructiveAgedEosinophiliaEosinophilsFemaleHumansImmunoglobulin ELeukocyte CountMaleMiddle AgedRespiratory SoundsRetrospective StudiesRisk FactorsImmunoglobulin EasthmaCOPDeosinophilfungal sensitizationwheezing

Identifiers

PMID41621870
PMCPMC13627635

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.