Evidence map›Paper›PMID 41621866›Full record

ArticleInternal medicine (Tokyo, Japan)2026

Cytotoxic Lesion of the Corpus Callosum in a Patient with Acute-on-chronic Lithium Toxicity.

Takeshi Miura, Teruki Kuroshita, Yosui Higuchi, Minori Ohno, Ayano Notsuyu, Takuya Fushino, Takahiro Ono, Natsumi Tomisawa, Keishun Boku, Yuki Enomoto and 1 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Takeshi MiuraDepartment of Emergency and Critical Care Medicine, University of Tsukuba Hospital, Japan.
Teruki KuroshitaDepartment of Psychiatry, Kashima Hospital, Japan.
Yosui HiguchiDepartment of Emergency and Critical Care Medicine, University of Tsukuba Hospital, Japan.
Minori OhnoDepartment of Emergency and Critical Care Medicine, University of Tsukuba Hospital, Japan.
Ayano NotsuyuDepartment of Emergency and Critical Care Medicine, University of Tsukuba Hospital, Japan.
Takuya FushinoDepartment of Emergency and Critical Care Medicine, University of Tsukuba Hospital, Japan.
Takahiro OnoDepartment of Emergency and Critical Care Medicine, University of Tsukuba Hospital, Japan.
Natsumi TomisawaDepartment of Emergency and Critical Care Medicine, University of Tsukuba Hospital, Japan.
Keishun BokuDepartment of Emergency and Critical Care Medicine, University of Tsukuba Hospital, Japan.
Yuki EnomotoDepartment of Emergency and Critical Care Medicine, University of Tsukuba Hospital, Japan.
Yoshiaki InoueDepartment of Emergency and Critical Care Medicine, University of Tsukuba Hospital, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 30-year-old woman with history of bipolar disorder presented to the emergency department with impaired consciousness and myoclonus following regular lithium treatment. Brain magnetic resonance imaging revealed a hyperintense lesion in the splenium of the corpus callosum, consistent with cytotoxic lesions of the corpus callosum (CLOCCs). Serum lithium levels were markedly elevated (3.54 mmol/L), and acute-on-chronic lithium toxicity was diagnosed. Hemodialysis and supportive care resulted in clinical and radiological recovery. This case highlights that CLOCCs may serve as important neuroimaging evidence of lithium toxicity and may support an early diagnosis and treatment, especially in patients with long-term lithium use.

Indexed as

Antimanic AgentsBipolar DisorderCorpus CallosumLithium CompoundsAdultFemaleHumansMagnetic Resonance ImagingRenal DialysisAntimanic AgentsLithium Compoundsbraincase reportcorpus callosumlithium toxicitymagnetic resonance imagingrenal dialysis

Identifiers

PMID41621866
PMCPMC13627499

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.