Severe Brain Atrophy after Allogeneic Hematopoietic Stem Cell Transplantation in a Patient Suffering from Chronic Graft-versus-host Disease.

Yasutaka Masuda, Akira Honda, Reo Yoshioka, Yusuke Baba, Atsushi Sudo, Tatsushi Toda, Mineo Kurokawa

Abstract readCase Reports

In one paragraph

Article in Internal medicine (Tokyo, Japan), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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5 · Who and what money

Authors and funding

7 authors.

Yasutaka MasudaDepartment of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, Japan.

Akira HondaDepartment of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, Japan.

Reo YoshiokaDepartment of Neurology, The University of Tokyo Hospital, Japan.

Yusuke BabaDepartment of Neurology, The University of Tokyo Hospital, Japan.

Atsushi SudoDepartment of Neurology, The University of Tokyo Hospital, Japan.

Tatsushi TodaDepartment of Neurology, The University of Tokyo Hospital, Japan.

Mineo KurokawaDepartment of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Allogeneic hematopoietic stem cell transplantation (HSCT) is associated with serious neurological sequelae in some patients. We herein present the case of a 30-year-old man who developed brain atrophy, especially in the bilateral medial temporal lobes approximately one year after undergoing HSCT for acute lymphoblastic leukemia. Together with myositis, which he concurrently experienced, and after ruling out other etiologies, the central nervous system (CNS) manifestations were considered to be chronic graft-versus-host disease. Both manifestations were refractory to steroid treatment and progressed when the patient was on ibrutinib. Previous reports on CNS complications of HSCT have been thoroughly reviewed, and the need for active surveillance and assessment of transplantation-related CNS alterations is also discussed.

Indexed as

BrainGraft vs Host DiseaseHematopoietic Stem Cell TransplantationAdultAtrophyChronic DiseaseHumansMalePrecursor Cell Lymphoblastic Leukemia-LymphomaTransplantation, Homologousallogeneic hematopoietic stem cell transplantationbrain atrophycentral nervous systemgraft-versus-host disease

Identifiers

PMID41621863

DOI10.2169/internalmedicine.5714-25

PMCPMC13668791

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.