Evidence map›Paper›PMID 41621714›Full record

ArticleJournal of lipid research2026

JNK1 mediates serine phosphorylation of STAT3 in response to fatty acids released by lipolysis.

A Melisa Aksu, Amena Akter, Preetveer Dhillon, Zane J Zerbel, Pania E Bridge-Comer, Oluwafemi Gbayisomore, Shannon M Reilly

Abstract read
In one paragraph

Article in Journal of lipid research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

A Melisa AksuDivision of Endocrinology and Metabolism, Department of Medicine, Weill Center for Metabolic Health, Weill Cornell Medicine, New York, NY, USA.
Amena AkterDivision of Endocrinology and Metabolism, Department of Medicine, Weill Center for Metabolic Health, Weill Cornell Medicine, New York, NY, USA; Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, USA.
Preetveer DhillonDivision of Endocrinology and Metabolism, Department of Medicine, Weill Center for Metabolic Health, Weill Cornell Medicine, New York, NY, USA.
Zane J ZerbelDivision of Endocrinology and Metabolism, Department of Medicine, Weill Center for Metabolic Health, Weill Cornell Medicine, New York, NY, USA.
Pania E Bridge-ComerDivision of Endocrinology and Metabolism, Department of Medicine, Weill Center for Metabolic Health, Weill Cornell Medicine, New York, NY, USA.
Oluwafemi GbayisomoreDivision of Endocrinology and Metabolism, Department of Medicine, Weill Center for Metabolic Health, Weill Cornell Medicine, New York, NY, USA.
Shannon M ReillyDivision of Endocrinology and Metabolism, Department of Medicine, Weill Center for Metabolic Health, Weill Cornell Medicine, New York, NY, USA. Electronic address: smr4005@med.cornell.edu.

Funding

Regulation of fatty acid metabolism in adipocytesR01DK126944 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI REILLY, SHANNON MARIE · 2021 to 2025
$2.1M
NIDDK NIH HHS R01 DK126944
6 · The paper itself

Abstract

Adipocytes play a central role in energy balance and metabolic health by storing excess nutrients as triglycerides in white adipose tissue. During physiological stress, sympathetic activation triggers lipolysis, releasing fatty acids and glycerol to meet systemic energy demands. Lipolytic activation in white adipocytes also increases their rate of oxygen consumption. Phosphorylation of signal transducer and activator of transcription 3 (STAT3) at Ser

Indexed as

Fatty AcidsLipolysisMitogen-Activated Protein Kinase 8SerineSTAT3 Transcription Factor3T3-L1 CellsAdipocytesAnimalsMicePhosphorylationFatty AcidsMitogen-Activated Protein Kinase 8SerineSTAT3 Transcription Factoradipocyteadipose tissuecell signalinglipid dropletslipolysis and fatty acid metabolismobesity

Identifiers

PMID41621714
PMCPMC12950406

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.