Evidence map›Paper›PMID 41621662›Full record

ArticleMucosal immunology2026

Depletion of CX3CR1

D Ai, L Kreyling, M A Battistone, M L Elizagaray, A Chen, S Bhushan, M Fijak, M Speckmann, G Michel, T Procida-Kowalski and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mucosal immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

D AiDepartment of Anatomy and Cell Biology, Unit of Reproductive Biology, Justus-Liebig University Giessen, Germany; Hessian Centre of Reproductive Medicine, Justus-Liebig University Giessen, Germany.
L KreylingDepartment of Anatomy and Cell Biology, Unit of Reproductive Biology, Justus-Liebig University Giessen, Germany; Hessian Centre of Reproductive Medicine, Justus-Liebig University Giessen, Germany.
M A BattistoneProgram of Membrane Biology, Nephrology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
M L ElizagarayProgram of Membrane Biology, Nephrology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
A ChenProgram of Membrane Biology, Nephrology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
S BhushanDepartment of Anatomy and Cell Biology, Unit of Reproductive Biology, Justus-Liebig University Giessen, Germany; Hessian Centre of Reproductive Medicine, Justus-Liebig University Giessen, Germany.
M FijakDepartment of Anatomy and Cell Biology, Unit of Reproductive Biology, Justus-Liebig University Giessen, Germany; Hessian Centre of Reproductive Medicine, Justus-Liebig University Giessen, Germany.
M SpeckmannFlow Cytometry Core Facility, Justus-Liebig University Giessen, Germany.
G MichelFlow Cytometry Core Facility, Justus-Liebig University Giessen, Germany.
T Procida-KowalskiBiomedical Informatics and System Medicine, Science Unit for Basic and Clinical Medicine, Justus-Liebig University Giessen, Germany.
M BartkuhnBiomedical Informatics and System Medicine, Science Unit for Basic and Clinical Medicine, Justus-Liebig University Giessen, Germany.
M SprangDepartment of Dermatology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
J U MayerDepartment of Dermatology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany; Research Center for Immunotherapy (FZI), University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany; Institute of Quantitative & Computational Biosciences, Johannes Gutenberg University Mainz, Mainz, Germany.
A MeinhardtDepartment of Anatomy and Cell Biology, Unit of Reproductive Biology, Justus-Liebig University Giessen, Germany; Hessian Centre of Reproductive Medicine, Justus-Liebig University Giessen, Germany.
C PleugerDepartment of Anatomy and Cell Biology, Unit of Reproductive Biology, Justus-Liebig University Giessen, Germany; Hessian Centre of Reproductive Medicine, Justus-Liebig University Giessen, Germany. Electronic address: christiane.pleuger@anatomie.med.uni-giessen.de.

Funding

Proton-secreting epithelial cells as key modulators of epididymal mucosal immunity - Administrative SupplementR01HD104672 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI Maria Agustina Battistone · 2021 to 2026
$2.5M
NICHD NIH HHS R01 HD104672
6 · The paper itself

Abstract

A finely tuned immune regulation within the epididymis and testis is essential for male reproductive health. This balance is especially critical in the epididymis, where sperm mature and ascending infections frequently disrupt homeostasis, resulting in regionally different immune responses and potential long-term fertility impairments. We previously demonstrated that the epididymis harbors a region-specific immunological scaffold, with CX3CR1

Indexed as

CX3C Chemokine Receptor 1EpididymisEscherichia coli InfectionsImmunologic SurveillanceMacrophagesTestisUropathogenic Escherichia coliAnimalsMaleMiceMice, TransgenicSpermatogenesisSpermatozoaCX3C Chemokine Receptor 1Cx3cr1 protein, mouseCX3CR1(+) macrophagesEpididymisEpididymitisEpithelial physiologyImmune regulationMale reproductive tractMononuclear phagocytesMucosal immunologySpermatogenesisSperm functionTestisUPEC

Identifiers

PMID41621662
PMCPMC13332447

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.