ReviewJournal of advanced research2026
Skin regeneration axis under metal-based nanozymes: from chronic wound healing to structural and functional restoration.
Review in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Probiotics and Extracellular Vesicles as Redox Modulators in Wound Healing: From Microbial Therapeutics to Engineered Nanotherapeutic Strategies.Antioxidants (Basel, Switzerland) · 2026Review
- Bilayer tri-dermal-network hydrogel for sequential delivery of PD-168077 in multimodal diabetic wound regeneration.Bioactive materials · 2026Article
- Polysaccharide based biomaterials for advanced wound healing applications.Frontiers in cellular and infection microbiology · 2026Review
- Bioadhesive hydrogels as immunomodulatory interfaces for chronic wound healing: from microenvironmental regulation mechanism to engineering strategies.Burns & trauma · 2026Review
- The Role and Mechanism of Nanozymes in Burn Wound Healing.International journal of nanomedicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiabetic infected wounds, representing a prototypical model of chronic non-healing wounds, leading to severe impairment of skin regeneration. However, complete skin restoration requires more than just wound closure; it crucially involves the inhibition of pathological scarring (fibrosis) and the functional regeneration of skin appendages (e.g., hair follicles). Metal-based nanozymes (MNZs), due to their highly stable, tunable enzyme-mimicking catalytic activity and excellent integration potential, have emerged as promising candidates, with initial studies demonstrating their utility in these broader regenerative aspects. But existing reviews primarily focus on MNZs' role in basic wound healing, overlooking the structure and functional regeneration potential of skin under MNZs intervention. AIM OF REVIEW: This review addresses the knowledge gap by analyzing the recent literature to establish a comprehensive "Skin Regeneration Axis" for MNZs application. Specifically, the objective is to integrate and evaluate MNZs' potential across the three essential dimensions of full-process skin repair: chronic wound healing, structural pathological scar inhibition, and functional appendage regeneration. This integration fully reports MNZs' potential for holistic skin restoration. KEY SCIENTIFIC CONCEPTS OF REVIEW: This review summarizes the fundamentals of MNZs, including their catalytic mechanisms, classifications, and synthetic strategies. It articulates a multidimensional regenerative paradigm for MNZs, elucidating their roles across the entire spectrum of skin regeneration, which constitutes the core concepts of this review: (1) Chronic Wound Healing via controlling inflammation and oxidative stress, (2) Pathological Scar Inhibition through targeted molecular pathway regulation, and (3) Structural Appendage Regeneration (e.g., hair follicles). The review also highlights critical translational challenges and proposes integrated strategies for accelerating the clinical application of MNZs for holistic skin repair.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.