ReviewBiotechnology advances
Strategies for controlled assembly of rod-shaped viral particles.
Review in Biotechnology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Nanoparticles are increasingly used in medical applications due to their precise control over size, shape, and surface properties, which enable safe, targeted delivery and controlled interactions with specific tissues and cell types, ultimately enhancing therapeutic outcomes. While synthetic nanoparticles have shown promise, they often face challenges related to toxicity, biocompatibility, and uniformity. In contrast, naturally derived particles offer inherent advantages, including biological compatibility and monodispersity, which help mitigate these issues. Rod-shaped viruses and virus-like particles (VLPs) are particularly attractive due to their directional assembly into hierarchical structures, uniform size, ease of surface functionalization, and tunable aspect ratio. These properties are useful to control biodistribution and cellular interactions for nanoparticle accumulation and targeted delivery in vivo. Ongoing efforts to harness rod-shaped virus-like particles for nanomedicine involve a variety of strategies to control assembly, such as genetic changes to coat proteins, RNA scaffold engineering, and physicochemical changes to the solution conditions. These strategies enable precise tuning of VLP shape, aspect ratio, and composition. This review summarizes available assembly strategies and highlights their impact on particle morphology. Limitations of current strategies and opportunities for implementing the currently known assembly techniques in nanomedicine are also discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.