Dynamic Contrast Enhanced-Magnetic Resonance Fingerprinting (DCE-MRF) Improves Detection of Induced Vascular Perfusion Reduction in a Mouse Breast Cancer Model.
Article in Magnetic resonance in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
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5 · Who and what money
Authors and funding
16 authors.
Christina J MacAskillDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.ORCID 0000-0003-0023-0044
Bernadette O ErokwuDepartment of Radiology, Case Western Reserve University, Cleveland, Ohio, USA.
Yuran ZhuDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.ORCID 0000-0003-2829-7451
Guanhua WangDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-1622-5664
Andrew DupuisDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.ORCID 0000-0002-3714-4812
Barbara J SchiemannCase Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA.
Gopalakrishnan RamamurthyDepartment of Radiology, Case Western Reserve University, Cleveland, Ohio, USA.
Chetan B DhakanDepartment of Medical Physics, University of Wisconsin, Madison, Wisconsin, USA.ORCID 0000-0003-1218-0320
Michael KavranDepartment of Radiology, Case Western Reserve University, Cleveland, Ohio, USA.
Chunying WuDepartment of Radiology, Case Western Reserve University, Cleveland, Ohio, USA.
William P SchiemannCase Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA.
Yilun SunDepartment of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, USA.
Mark A GriswoldDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.
Xin YuDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.ORCID 0000-0001-8996-0267
Mark D PagelDepartment of Medical Physics, University of Wisconsin, Madison, Wisconsin, USA.ORCID 0000-0002-8109-3995
Chris A FlaskDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.
Funding
TUMOR METABOLISM PROGRAMP30CA043703 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI Amar Desai · 1987 to 2026
$142.3M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007250 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI HUANG, ALEX YEE-CHEN · 1985 to 2023
$33.4M
Clinical and Translational Science Collaborative of Northern Ohio, Catalyzing Linkages to Equity in Health (CLE Health)UM1TR004528 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI GRACE A MCCOMSEY · 2023 to 2026
$32.1M
Interdisciplinary Biomedical Imaging Training ProgramT32EB007509 · NIBIB · CASE WESTERN RESERVE UNIVERSITY · PI DAVID Lynn WILSON, Xin Yu · 2007 to 2026
$5.6M
AQP4 and glymphatic function in post-stroke recoveryR01NS124206 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI Christopher A Flask, Xin Yu · 2022 to 2026
$2.8M
Magnetic Resonance Fingerprinting of Tumor Vascular Perfusion and AcidosisR01CA269354 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI Christopher A Flask, Mark David Pagel · 2023 to 2026
$2.6M
PET Insert for Preclinical PET-MRIS10OD030499 · OD · CASE WESTERN RESERVE UNIVERSITY · PI FLASK, CHRISTOPHER A · 2021 to 2021
purposeDynamic contrast-enhanced MRI (DCE-MRI) can assess tumor perfusion using pharmacokinetic models. However, poor DCE-MRI reproducibility from reliance on conventional T
methodsTwenty female mice bearing orthotopic 4 T1 breast tumors were randomly assigned to DCE-MRF (n = 12) or conventional DCE-MRI (n = 8) cohorts. Both methods acquired matched spatial and temporal resolution (23-s) T
resultsDCE-MRF demonstrated 1.3-to-5.1-fold larger effect sizes for RK
conclusionsDCE-MRF's improved measurement precision and increased effect size translates directly to enhanced statistical power for detecting treatment-induced vascular changes, positioning it as a more reproducible tumor perfusion assessment for animal models and eventually cancer patients.
Indexed as
Breast NeoplasmsMagnetic Resonance ImagingMammary Neoplasms, ExperimentalNeovascularization, PathologicAnimalsContrast MediaDisease Models, AnimalDynamic Contrast Enhanced Magnetic Resonance ImagingFemaleMicePerfusion Magnetic Resonance ImagingReproducibility of ResultsStilbenesContrast MediafosbretabulinStilbenesbreast cancerDCE‐MRIdynamic contrast enhanced MRImouse modelsMR fingerprintingperfusionpharmacokinetic modeling
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Dynamic Contrast Enhanced-Magnetic Resonance Fingerprinting (DCE-MRF) Improves Detection of Induced Vascular Perfusion Reduction in a Mouse Breast Cancer Model. · full record | OpenQuestion