Trial reportBMC psychology2026
Sex differences in treatment outcomes among U.S. service members with comorbid PTSD and MDD.
Trial report in BMC psychology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02874131 (Behavioral Activation + Cognitive Processing Therapy for Posttraumatic Stress Disorder and Comorbid Major Depressive Disorder), which is not on this map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Behavioral Activation + Cognitive Processing Therapy for Posttraumatic Stress Disorder and Comorbid Major Depressive Disorder
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPosttraumatic stress disorder (PTSD) and major depressive disorder (MDD) are prevalent and deleterious conditions that commonly co-occur among service members. Identifying factors such as sex that could be linked to treatment response among service members with these conditions is critical for improving care delivery.
methodsThis study examined sex differences in treatment outcomes among U.S. active duty service members with comorbid PTSD and MDD (N = 94; 55% women, 45% men) in a randomized controlled trial comparing behavioral activation-enhanced cognitive processing therapy (BA + CPT) and standard CPT. PTSD and MDD symptom severity was assessed at pretreatment, posttreatment, and 3-month follow-up.
resultsIntent-to-treat multilevel models indicated treatment condition moderated the relationship between sex and PTSD symptoms (p = .020) but not depression (p = .16). On average, Clinician-Administered PTSD Scale for DSM-5 scores decreased significantly more among servicewomen who received CPT versus BA + CPT at posttreatment (p = .004) and 3-month follow-up (p = .049). There were no significant differences in outcomes among servicemen (ps > 0.05). In CPT, servicewomen reported significantly greater PTSD symptom reduction compared to servicemen at posttreatment (p = .039) but not at follow-up (p = .088). In BA + CPT, PTSD symptoms did not significantly differ between sexes at posttreatment (p = .054) or follow-up (p = .29).
conclusionsFindings suggest sex may differentially impact outcomes for CPT but not BA + CPT among service members with PTSD and MDD and could help inform shared decision-making between patients and providers.
trial registrationClinicalTrials.gov registry; registration number NCT02874131; date of registration: 08-22-2016.
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