SynthesisMalaria journal2026
Clinical characteristics and outcome of malaria-associated acute kidney injury in adult patients: a systematic review and meta analysis.
Synthesis in Malaria journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- KDIGO stage 3 acute kidney injury in children with severe Plasmodium falciparum malaria including blackwater fever: a case series from a resource-limited setting in Southwest Ethiopia.BMC nephrology · 2026Article
- Heat shock protein Gp96 (Grp94) in malaria: functional insights at the host-parasite interface and therapeutic perspectives.Frontiers in cell and developmental biology · 2026Review
Corrections and comments
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Authors and funding
7 authors.
Funding
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Abstract
backgroundMalaria-associated acute kidney injury (MAKI) represents a severe complication of malaria, increasingly documented in both Plasmodium falciparum and Plasmodium vivax infections across endemic regions.
methodsA systematic review and metaanalysis using PubMed, EMBASE, and Cochrane CENTRAL was conducted to identify studies published between 2000 and 2024. This review evaluates the existing literature on MAKI in adult population, aiming to synthesize data on demographics, Plasmodium species, kidney involvement, dialysis need, mortality, kidney histopathology, and long-term kidney outcomes.
resultsThe review included 25 studies with 2,094 MAKI patients predominantly from South Asia, especially India followed by Pakistan and Thailand. Plasmodium falciparum was the most common species implicated, though severe AKI due to P. vivax was increasingly reported. AKI definitions varied, using serum creatinine thresholds or classifications like KDIGO, RIFLE, and WHO. The incidence of MAKI ranged from 2.4 to 45.5%, rising to as high as 77% among patients with severe malaria. The pooled incidence of AKI among adults patients with malaria was 26.5% (95% CI 19.8-34.4; I
conclusionMAKI is a severe complication of malaria with regional variation in species, outcomes, and care access. Improved diagnostics, timely dialysis, and long-term nephrology follow-up are essential in endemic regions.
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