ReviewDiabetology & metabolic syndrome2026
Myocardial ischemia reperfusion in diabetes: mechanism of injury and its drug treatment.
Review in Diabetology & metabolic syndrome, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetes with myocardial ischemia-reperfusion injury(MIRI) represents a common complication of diabetes mellitus (DM), and cardiovascular disease remains the leading cause of death in DM patients. Consequently, preventing cardiovascular disease in individuals with diabetes continues to pose a significant challenge. Hyperglycemia-induced elevation of reactive oxygen species (ROS), activation of ferroptosis, and impairment of cardioprotective pathways collectively increase diabetic patients’ susceptibility to myocardial ischemia. MIRI, characterized by oxygen deprivation followed by restoration of blood flow, causes irreversible tissue damage. The pathophysiological mechanisms underlying MIRI in diabetes involve ferroptosis, oxidative stress, inflammation, intracellular calcium overload, and endoplasmic reticulum stress. These mechanisms interact synergistically to directly or indirectly aggravate myocardial damage. This review aims to achieve two objectives: first, to summarize the underlying pathogenic mechanisms of MIRI in DM; second, to outline the pharmacological effects and molecular targets of therapeutic agents for diabetic MIRI.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.