Evidence map›Paper›PMID 41620676›Full record

Trial reportBMC anesthesiology2026

High-flow nasal oxygen versus face-mask ventilation for rapid sequence induction in non-elective surgical patients: a randomized controlled trial.

Nguyen Duc Lam, Le Dinh Thanh Son, Tran Minh Phat, Nguyen Dang Thu, Nguyen Thuy Nga, Vuong Trung Son, Bui Minh Hong

Registry-linked trialAbstract readRandomized Controlled TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC anesthesiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06879600 (Research on Pre-Anesthetic Blood Oxygenation Effect of High-Flow Nasal Oxygen for Emergency Surgery Patients With Full Stomachs), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06879600 narecruitingnot on this map

Research on Pre-Anesthetic Blood Oxygenation Effect of High-Flow Nasal Oxygen for Emergency Surgery Patients With Full Stomachs

TypeinterventionalSponsorNguyen Dang ThuRan2023 to 2026Enrolled200ConditionsHigh-flow Nasal Cannula, Oxygenation, General Anesthesia, Induction AnesthesiaArmsHigh-flow nasal cannula therapy application, Traditional facemask
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nguyen Duc Lam *Department of Anesthesiology and Resuscitation, Hanoi Medical University, No. 01, Ton That Tung Street, Kim Lien Ward, Hanoi, 11520, Vietnam.
Le Dinh Thanh SonDepartment of Anesthesiology and Resuscitation, Phu Tho Provincial General Hospital, Nguyen Tat Thanh Street, Viet Tri Ward, Phu Tho, 35129, Vietnam.
Tran Minh PhatDepartment of Anesthesiology and Resuscitation, Phu Tho Provincial General Hospital, Nguyen Tat Thanh Street, Viet Tri Ward, Phu Tho, 35129, Vietnam.
Nguyen Dang ThuDepartment of Anesthesiology, Military Hospital 103, Vietnam Military Medical University, No.261 Phung Hung Street, Ha Dong Ward, Hanoi, 12123, Vietnam.ORCID http://orcid.org/0000-0002-1326-3681
Nguyen Thuy NgaDepartment of Anesthesiology and Resuscitation, Phu Tho Provincial General Hospital, Nguyen Tat Thanh Street, Viet Tri Ward, Phu Tho, 35129, Vietnam.
Vuong Trung SonDepartment of Anesthesiology and Resuscitation, Phu Tho Provincial General Hospital, Nguyen Tat Thanh Street, Viet Tri Ward, Phu Tho, 35129, Vietnam.
Bui Minh Hong *Department of Anesthesiology and Resuscitation, Hanoi Medical University, No. 01, Ton That Tung Street, Kim Lien Ward, Hanoi, 11520, Vietnam. drhong88gmhs@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients undergoing non-elective surgery frequently require rapid sequence induction (RSI) because of concerns related to recent oral intake, impaired gastric emptying, or uncertain fasting status. Previous randomized controlled trials have reported mixed results regarding the effectiveness of high-flow nasal cannula (HFNC) in preventing oxygen desaturation during RSI. This study evaluated the effect of HFNC compared with facemask ventilation (FMV) during RSI in a non-elective surgical population.

methodsIn this randomized controlled study, adult ASA I-II patients undergoing non-elective surgery were allocated to HFNC (100% O₂, 60 L·min⁻

resultsAmong 214 analyzed patients (107 per group), no desaturation events (SpO₂ < 94%) occurred in the HFNC group versus 12.1% in FMV (p < 0.001). HFNC yielded higher PaO₂ after preoxygenation (445.7 ± 16.8 vs. 314.2 ± 14.5 mmHg) and after intubation (405.5 ± 17.7 vs. 236.5 ± 58.5 mmHg; both p < 0.001). End-tidal oxygen concentrations were also higher with HFNC (86.0 ± 11.4% vs. 75.7 ± 12.3%; p < 0.001). CO₂ accumulation, hemodynamic variables, gastric volume, and aspiration incidence were similar between groups. Mild nasal dryness reduced comfort with HFNC, and one patient withdrew because of discomfort; overall tolerance remained acceptable.

conclusionHFNC appeared to improve oxygenation compared with FMV in this low-risk, non-elective surgical cohort. Within the limits of this physiologically stable population, HFNC was well tolerated and did not increase measured gastric or hemodynamic complications.

trial registrationClinicalTrials, NCT06879600. Retrospectively registered on 05 March 2025, https://clinicaltrials.gov/study/NCT06879600 .

Indexed as

OxygenOxygen Inhalation TherapyRapid Sequence Induction and IntubationAdultAgedCannulaFemaleHumansMaleMasksMiddle AgedRetrospective StudiesOxygenApneic oxygenationFace mask ventilationHigh-flow nasal cannulaNon-elective surgeryPreoxygenationRapid sequence induction

Identifiers

PMID41620676
PMCPMC12947341

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.