ArticleEuropean journal of medical research2026
PD-L1 status on circulating tumor cells: a promising predictor in advanced lung cancer with PD-1/PD-L1 immunotherapies.
Article in European journal of medical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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6 authors.
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Abstract
backgroundTumor heterogeneity and invasive sampling limit traditional tissue-based PD-L1 testing in advanced lung cancer. We explored a non-invasive alternative by assessing PD-L1 expression on circulating tumor cells (CTC PD-L1) via liquid biopsy to predict immunotherapy outcomes.
methodsFifty-two advanced lung cancer patients were recruited, and 38 individuals received a combination of chemotherapy and PD-1/PD-L1 inhibitor therapy, with serial blood samples (baseline, during treatment, and at progression) analyzed using the LiquidBiopsy
resultsCTC PD-L1 was identified on special phenotype with a ratio of CK/CD45 > 1.7 and PD-L1/CD45 > 3.2. At baseline, 71.2% (37/52) of patients had detectable CTCs, with 50.0% (26/52) being CTC PD-L1
conclusionsWe developed a novel procedure to detect and characterize PD-L1 expression on CTCs, which was a feasible, non-invasive biomarker for potentially predicting the combination of chemotherapy and immunotherapy efficacy in advanced lung cancer, addressing tissue sampling limitations and enhancing patient stratification and monitoring.
trial registrationThe study was approved by the Medical Ethics Committee of Fourth Affiliated Hospital of Soochow University, with ethics approval number 220154 on 23th January, 2022 and retrospectively registered under clinical trial number ChiCTR2500096312 on 21th January, 2025.
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