ArticleJournal of neuroengineering and rehabilitation2026
Electrical or magnetic nerve stimulation enhance the BoNT/A-mediated muscle paralysis.
Article in Journal of neuroengineering and rehabilitation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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2 authors.
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Abstract
backgroundBotulinum toxin type A (BoNT/A) is first-line treatment for muscle spasticity but the dose can be limited by side effects depending on the treated muscle mass and location. Stimulation of peripheral motor nerves upon BoNT/A injection into the innervated muscles may be a technique to increase the BoNT/A effect without increasing the dose. Our goal was to study the augmentation of the BoNT/A effect by transcutaneous electrical (TENS) or magnetic nerve stimulation (MS) in a mouse model.
methodsThe paralytic effect of BoNT/A with or without TENS was evaluated with the mouse digit abduction score (DAS) at 20, 30, and 40 U/kg. The paralytic effect of BoNT/A with or without peripheral MS was evaluated with the mouse DAS at 20 or 30 U/kg.
resultsAfter 20 U/kg BoNT/A treatment combined with TENS the DAS was higher and showed a longer duration of paralysis than without TENS. After 30 U/kg BoNT/A treatment combined with magnetic stimulation the DAS was higher than without magnetic stimulation.
conclusionWe established an electrical and a magnetic nerve stimulation protocol combined with BoNT/A treatment in mice. Combination of i.m. BoNT/A injection with TENS or MS demonstrated an enhanced BoNT/A effect as compared to non-stimulated groups. Despite limitations of the magnetic stimulation method in the mouse our data revives the discussion of BoNT/A effect augmentation by stimulating the injected muscles' efferent nerves during the BoNT/A uptake phase.
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