ArticleRespiratory research2026
Characteristics and significance of bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation at bronchoscopy.
Article in Respiratory research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo observe and analyse the characteristic endoscopic findings and clinical significance of bronchiolitis obliterans syndrome(BOS) after hematopoietic stem cell transplantation(HSCT) under ultrathin bronchoscopy.
methodsThe clinical data and characteristic images under bronchoscopy of 51 patients diagnosed with BOS after HSCT in the Department of Respiratory and Critical Care Medicine of the Fourth Affiliated Hospital of Soochow University from December 2020 to December 2023 were collected. Pearson’s correlation was used to analyse the correlation between the occlusion level with the percent predicted forced expiratory volume in 1 s (FEV1% pred) and the percent predicted of forced expiratory volume in 1 s/forced vital capacity (FEV1/FVC); Kaplan-Meier survival analysis and COX regression analysis were used to analyze the relationship between the characteristics under endoscopy and survival.
resultsThere were four different manifestations of bronchioles under bronchoscopy: (1)membranous occlusion, (2)scar hyperplasia occlusion; (3)bronchial concentric stenosis, (4)only increased mucus. Spearman’s correlation coefficients of occlusion level with FEV1%pred and FEV1/FVC were 0.40 and 0.41, respectively. The closer the occlusion level was to the central airway, the lower the FEV1%pred and FEV1/FVC, and the two were positively correlated. The cut-off values of pulmonary function indices in the occluded population, FEV1%pred < 49.85% and FEV1/FVC < 62.23%. COX regression analyses showed that bronchial occlusion level≤ 8th-level bronchus(HR = 12.882, 95% CI: 1.595–104.030, p = 0.016) was an important risk factor affecting the survival of BOS patients.
conclusionPatients with BOS can present in various forms of bronchial occlusion; the bronchial occlusion level was positively correlated with the decline in pulmonary function; the level of occluded bronchi being ≤ 8th-level bronchus is a risk factor affecting the survival of BOS patients.
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